Increased oxidative stress in children with attention deficit hyperactivity disorder

被引：45

作者：

Sezen, Hatice ^{[1
]}

Kandemir, Hasan ^{[2
]}

Savik, Emin ^{[1
]}

Kandemir, Sultan Basmaci ^{[3
]}

Kilicaslan, Fethiye ^{[2
]}

Bilinc, Hasan ^{[1
]}

Aksoy, Nurten ^{[1
]}

机构：

[1] Harran Univ, Dept Clin Biochem, Fac Med, Sanliurfa, Turkey

[2] Harran Univ, Dept Child & Adolescent Psychiat, Fac Med, Sanliurfa, Turkey

[3] Balikligol State Hosp, Dept Psychiat, Sanliurfa, Turkey

来源：

REDOX REPORT | 2016年 / 21卷 / 06期

关键词：

Attention deficit hyperactivity disorder; Oxidative stress; Paraxonase-1; Arylesterase; ARYLESTERASE ACTIVITIES; SERUM PARAOXONASE; ADOLESCENT PATIENTS; AUTOMATED-METHOD; LIPID PROFILE; IMBALANCE; PREVALENCE; ADHD;

D O I：

10.1080/13510002.2015.1116729

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Objectives: The purpose of this study was to investigate oxidative stress in children with attention deficit hyperactivity disorder (ADHD). Methods: Total oxidant status (TOS), total antioxidant status (TAS), paraxonase-1 (PON-1) and arylesterase (ARE) activity were measured in 76 children (44 boys, 32 girls) diagnosed with ADHD according to the DSM-IV and 78 healthy children (46 boys, 32 girls). Results: Age and sex were similar between the groups (P > 0.05). TOS and the oxidative stress index (OSI) were higher in the patient group than the control group (P < 0.001). PON-1 (P = 0.002), ARE (P = 0.010) activity and TAS (P < 0.001) were lower in the patient group than the control group. Discussion: We found decreased PON-1, ARE activity and TAS, and increased TOS and OSI in children with ADHD. Our study showed that there is significantly increased oxidative stress in children with ADHD.

引用

页码：248 / 253

页数：6

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