Elevated Melatonin Levels in Children With Attention Deficit Hyperactivity Disorder: Relationship to Oxidative and Nitrosative Stress

被引：10
|
作者：
Avcil, Sibelnur [1 ]
Uysal, Pinar [1 ]
Yenisey, Cigdem [2 ]
Abas, Burcin Irem [3 ]
机构：
[1] Adnan Menderes Univ, Fac Med, Dept Child & Adolescent Psychiat, TR-09200 Aydin, Turkey
[2] Adnan Menderes Univ, Fac Med, Dept Biochem, Aydin, Turkey
[3] Adnan Menderes Univ, Fac Med, Dept Biochem, Biochem, Aydin, Turkey
来源：
JOURNAL OF ATTENTION DISORDERS | 2021年 / 25卷 / 05期
关键词：
ADHD; melatonin; nitric oxide; malondialdehyde; oxidative stress; NITRIC-OXIDE; LIPID-PEROXIDATION; NONSELECTIVE ATTENTION; SUPEROXIDE-DISMUTASE; ANTIOXIDANT DEFENSE; ADOLESCENT PATIENTS; MAJOR DEPRESSION; SERUM; SCHIZOPHRENIA; DOPAMINE;
D O I：
10.1177/1087054719829816
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Objective: The aim of this article is to measure serum antioxidant melatonin, the oxidants of nitric oxide, and malondialdehyde levels to calculate the serum oxidant-antioxidant balance based on the nitric oxide/melatonin and malondialdehyde/melatonin ratios in children with ADHD. Method: The serum melatonin, nitric oxide, malondialdehyde, and the nitric oxide/melatonin and malondialdehyde/melatonin ratios were calculated and compared between the children with ADHD (n = 103) and healthy control participants (n = 73). Results: Serum melatonin and nitric oxide levels were higher, and the nitric oxide/melatonin and malondialdehyde/melatonin ratios were lower in ADHD children than the control group. Melatonin was found to be significantly high, and the malondialdehyde/melatonin ratio was found to be significantly low in children with a positive ADHD family history. Conclusion: The serum oxidant-antioxidant balance was impaired in children with ADHD. Within the ADHD group, higher melatonin levels were determined in the children with a positive family history.
引用
收藏
页码：693 / 703
页数：11
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