AGE-RELATED ULTRASTRUCTURAL AND MONOAMINE OXIDASE CHANGES IN THE RAT OPTIC NERVE

被引：1

作者：

Taurone, S. ^{[1
]}

Ripandelli, G. ^{[1
]}

Minni, A. ^{[2
]}

Lattanzi, R. ^{[3
]}

Miglietta, S. ^{[4
]}

Pepe, N. ^{[4
]}

Fumagalli, L. ^{[4
]}

Micera, A. ^{[1
]}

Pastore, F. S. ^{[5
]}

Artico, M. ^{[2
]}

机构：

[1] IRCCS GB Bietti Fdn, Rome, Italy

[2] Sapienza Univ Rome, Dept Sensory Organs, Vle Policlin 155, I-00161 Rome, Italy

[3] Sapienza Univ Rome, Dept Physiol & Pharmacol Vittorio Erspamer, Rome, Italy

[4] Sapienza Univ Rome, Anat Histol Medicolegal & Locomotor Syst Sci, Rome, Italy

[5] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy

来源：

JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS | 2016年 / 30卷 / 03期

关键词：

optic nerve; age-related changes; MAO enzymes; light microscopy; histochemistry; transmission electron microscopy; B INHIBITORS; MICE;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this paper is to study the morphology and the distribution of the monoamine oxidase enzymatic system in the optic nerve of 4 month-old Wistar (young) and 28 month-old Wistar (old) rats. The optic nerve was harvested from 20 young and old rats. The segment of optic nerve was divided longitudinally into two pieces, each 0.1 mm in length. The first piece was used for transmission electron microscopy. The second piece was stained with histochemical reaction for monoamine oxidase. The age related changes in the optic nerve of rats include micro-anatomical details, ultrastructure and monoamine oxidase histochemical staining. A strong decrease of the thin nerve fibers and a swelling of the thick ones can be observed in optic nerve fibers of old rats. Increased monoamine oxidase histochemical staining of the optic nerve of aged rats is well demonstrated. The increase of meningeal shealth and the decrease of thin nerve fibers of the optic nerve in old rats are well documented. Morphological, ultrastructural and histochemical changes observed in optic nerve fibers of the old rats show a close relation with aging.

引用

页码：903 / 908

页数：6

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