Age-related changes in nociception, behavior, and monoamine levels in rats

被引：31
|
作者：
Goicoechea, C [1 ]
Ormazabal, MJ [1 ]
Alfaro, MJ [1 ]
Martin, MI [1 ]
机构：
[1] UNIV COMPLUTENSE MADRID,SCH MED,DEPT PHARMACOL,E-28040 MADRID,SPAIN
来源：
GENERAL PHARMACOLOGY | 1997年 / 28卷 / 02期
关键词：
aged-rats; pain; behavior; monoamines;
D O I：
10.1016/S0306-3623(96)00222-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. Pain threshold, behavioral parameters, and monoamine levels were compared in two groups of rats: adult (12 months old) and old rats (25 months old). 2. No differences in nociception were found between the two groups using the tail-shock test. 3. Behavioral experiments with the holeboard test showed that locomotor activity and exploration activity were lower in aged animals, whereas no significant differences were found in emotivity. 4. Using high-performance liquid chromatography (HPLC) techniques, we found that serotonin and dopamine showed lower levels in the old group. Copyright (C) 1997 Elsevier Science Inc.
引用
收藏
页码：331 / 336
页数：6
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