Age-related changes of the monoamine oxidases in rat heart

被引：0
|
作者：
Cavallotti, C
Mancone, M
Artico, M
Cavallotti, D
机构：
[1] Univ Roma La Sapienza, Dept Cardiovasc & Resp Sci, I-00161 Rome, Italy
[2] Univ Rome, Dept Pharmacol Nat Mol & Gen Physiol, Rome, Italy
[3] S Spirito Hosp, Serv Neurol, Rome, Italy
来源：
BIOMEDICAL RESEARCH-TOKYO | 2002年 / 23卷 / 02期
关键词：
D O I：
10.2220/biomedres.23.109
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Levels and distribution of heart monoamine oxidases (MAOs) were studied in male Sprague-Dawley rats of 3 (young) and 24 (old) months of age using biochemical and histochemical techniques. Biochemical assay of MAOs in atria and in ventricles showed a significant increase in MAOs levels in old in comparison with young animals. MAOs histochemical staining revealed an homogeneous distribution of the enzyme within both right and left atria and/or ventricles in 3-months-old rats. In 24-months-old rats an increase of MAOs reaction in comparison with younger animals was found. This increase is more consistent in the endocardial portion of the right atrium and in the endocardial portion of the left atrium. In 3-months-old rats MAOs reaction was slightly lower in the epicardial than in the endocardial portions of both atria and/or ventricles. In 24-months-old rats MAOs reaction showed a significant increase if compared with young rats. The significance of these data is discussed in relation to the role of MAOs in rat heart.
引用
收藏
页码：109 / 113
页数：5
相关论文
共 50 条
  • [1] AGE-RELATED ULTRASTRUCTURAL AND MONOAMINE OXIDASE CHANGES IN THE RAT OPTIC NERVE
    Taurone, S.
    Ripandelli, G.
    Minni, A.
    Lattanzi, R.
    Miglietta, S.
    Pepe, N.
    Fumagalli, L.
    Micera, A.
    Pastore, F. S.
    Artico, M.
    [J]. JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2016, 30 (03): : 903 - 908
  • [2] Monoamine oxidase enzymes and oxidative stress in the rat optic nerve: age-related changes
    Nebbioso, Marcella
    Pascarella, Antonia
    Cavallotti, Carlo
    Pescosolido, Nicola
    [J]. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 2012, 93 (06) : 401 - 405
  • [3] AGE AND CHANGES IN RAT HEART MONOAMINE OXIDASE ACTIVITY
    HORITA, A
    [J]. PHARMACOLOGIST, 1966, 8 (02): : 177 - &
  • [4] AGE-RELATED CHANGES IN RAT TONGUE
    Pirovski, Nikola
    Atanasova, Dimitrinka
    Keskinova, Donka
    Dimitrov, Nikolay
    [J]. COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES, 2023, 76 (09): : 1368 - 1377
  • [5] Age-related changes in the rat hippocampus
    Is, Merih
    Comunoglu, Nil Ustundag
    Comunoglu, Cem
    Eren, Bulent
    Ekici, Isin Dogan
    Ozkan, Ferda
    [J]. JOURNAL OF CLINICAL NEUROSCIENCE, 2008, 15 (05) : 568 - 574
  • [6] Age-related changes in rat retina
    Cavallotti, C
    Artico, M
    Pescosolido, N
    Feher, J
    [J]. JAPANESE JOURNAL OF OPHTHALMOLOGY, 2001, 45 (01) : 68 - 75
  • [7] Age-related changes in sleep in the rat
    Mendelson, WB
    Bergmann, BM
    [J]. SLEEP, 1999, 22 (02): : 145 - 150
  • [8] Age-related changes in nociception, behavior, and monoamine levels in rats
    Goicoechea, C
    Ormazabal, MJ
    Alfaro, MJ
    Martin, MI
    [J]. GENERAL PHARMACOLOGY, 1997, 28 (02): : 331 - 336
  • [9] Age-related changes in endothelin-1 receptor subtypes in rat heart
    Del Ry, Silvia
    Maltinti, Maristella
    Giannessi, Daniela
    Cavallini, Gabriella
    Bergamini, Ettore
    [J]. EXPERIMENTAL AGING RESEARCH, 2008, 34 (03) : 251 - 266
  • [10] Age-related changes in catecholaminergic nerve fibers of rat heart and coronary vessels
    Bruzzone, P
    Cavallotti, C
    Mancone, M
    Leali, FMT
    [J]. GERONTOLOGY, 2003, 49 (02) : 80 - 85
12345