Tackling Inflammatory Bowel Diseases: Targeting Proinflammatory Cytokines and Lymphocyte Homing
被引:17
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作者:
Song, Yijie
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机构:
Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R ChinaShanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
Song, Yijie
[1
]
Yuan, Man
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Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R ChinaShanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
Yuan, Man
[1
]
Xu, Yu
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Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R ChinaShanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
Xu, Yu
[1
]
Xu, Hongxi
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Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Shanghai 201203, Peoples R ChinaShanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
Xu, Hongxi
[2
]
机构:
[1] Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Shanghai 201203, Peoples R China
Inflammatory bowel diseases (IBDs) are characterized by chronic inflammatory disorders that are a result of an abnormal immune response mediated by a cytokine storm and immune cell infiltration. Proinflammatory cytokine therapeutic agents, represented by TNF inhibitors, have developed rapidly over recent years and are promising options for treating IBD. Antagonizing interleukins, interferons, and Janus kinases have demonstrated their respective advantages in clinical trials and are candidates for anti-TNF therapeutic failure. Furthermore, the blockade of lymphocyte homing contributes to the excessive immune response in colitis and ameliorates inflammation and tissue damage. Factors such as integrins, selectins, and chemokines jointly coordinate the accumulation of immune cells in inflammatory regions. This review assembles the major targets and agents currently targeting proinflammatory cytokines and lymphatic trafficking to facilitate subsequent drug development.
机构:
Shinshu Univ, Grad Sch Med, Dept Mol Pathol, Matsumoto, Nagano 3908621, JapanSanford Burnham Med Res Inst, Canc Res Ctr, Tumor Microenvironm Program, La Jolla, CA 92037 USA
Kobayashi, Motohiro
Hoshino, Hitomi
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Shinshu Univ, Grad Sch Med, Dept Mol Pathol, Matsumoto, Nagano 3908621, Japan
Natl Inst Longev Sci, Dept Alzheimers Dis Res, Obu 4748511, JapanSanford Burnham Med Res Inst, Canc Res Ctr, Tumor Microenvironm Program, La Jolla, CA 92037 USA
Hoshino, Hitomi
Suzawa, Kenichi
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机构:
Shinshu Univ, Grad Sch Med, Dept Mol Pathol, Matsumoto, Nagano 3908621, JapanSanford Burnham Med Res Inst, Canc Res Ctr, Tumor Microenvironm Program, La Jolla, CA 92037 USA
Suzawa, Kenichi
Sakai, Yasuhiro
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Shinshu Univ, Grad Sch Med, Dept Mol Pathol, Matsumoto, Nagano 3908621, JapanSanford Burnham Med Res Inst, Canc Res Ctr, Tumor Microenvironm Program, La Jolla, CA 92037 USA
Sakai, Yasuhiro
Nakayama, Jun
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Shinshu Univ, Grad Sch Med, Dept Mol Pathol, Matsumoto, Nagano 3908621, JapanSanford Burnham Med Res Inst, Canc Res Ctr, Tumor Microenvironm Program, La Jolla, CA 92037 USA
Nakayama, Jun
Fukuda, Minoru
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Sanford Burnham Med Res Inst, Canc Res Ctr, Tumor Microenvironm Program, La Jolla, CA 92037 USASanford Burnham Med Res Inst, Canc Res Ctr, Tumor Microenvironm Program, La Jolla, CA 92037 USA
机构:
Hosp Civils Lyon, Lyon, France
Univ Claude Bernard Lyon 1, Lyon, France
Canc Res Ctr Lyon CRCL, Tumor Escape Resistance & Immun Dept, Inserm U1052, CNRS,UMR 5286, Lyon, France
French Fecal Transplant Grp, Paris, FranceHosp Civils Lyon, Lyon, France
Benech, Nicolas
Sokol, Harry
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French Fecal Transplant Grp, Paris, France
Sorbonne Univ, Ctr Rech St Antoine, INSERM UMRS 938, CRSA,AP HP, Paris, France
St Antoine Hosp, Gastroenterol Dept, APHP, Paris, France
Paris Ctr Microbiome Med PaCeMM FHU, Paris, France
AgroParisTech, Micalis Inst, INRAe, Jouy En Josas, FranceHosp Civils Lyon, Lyon, France
机构:
Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USAUniv Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA
Garth, Jaleesa
Barnes, Jarrod W.
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Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USAUniv Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USA
机构:
Univ Erlangen Nurnberg, Dept Med 1, Kussmaul Campus Med Res & Translat Res Ctr, D-91054 Erlangen, GermanyUniv Erlangen Nurnberg, Dept Med 1, Kussmaul Campus Med Res & Translat Res Ctr, D-91054 Erlangen, Germany
Zundler, S.
Neurath, M. F.
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Univ Erlangen Nurnberg, Dept Med 1, Kussmaul Campus Med Res & Translat Res Ctr, D-91054 Erlangen, GermanyUniv Erlangen Nurnberg, Dept Med 1, Kussmaul Campus Med Res & Translat Res Ctr, D-91054 Erlangen, Germany
机构:
Univ Tehran Med Sci, Shariati Hosp, DDRI, Tehran, IranUniv Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Int Campus, Tehran, Iran
Vahedi, H.
Hemmasi, G.
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机构:
Iran Univ Med Sci, Dept Internal Med & Gastroenterol, Tehran, IranUniv Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Int Campus, Tehran, Iran
Hemmasi, G.
Khameneh, A. Moussavi Nasl
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TUMS IC, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Int Campus, Tehran, IranUniv Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Int Campus, Tehran, Iran
Khameneh, A. Moussavi Nasl
Parastouei, K.
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TUMS IC, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Int Campus, Tehran, IranUniv Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Int Campus, Tehran, Iran
Parastouei, K.
Saboor-Yaraghi, A. A.
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Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Int Campus, Tehran, IranUniv Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Int Campus, Tehran, Iran