Tackling Inflammatory Bowel Diseases: Targeting Proinflammatory Cytokines and Lymphocyte Homing

被引：17
|
作者：
Song, Yijie [1 ]
Yuan, Man [1 ]
Xu, Yu [1 ]
Xu, Hongxi [2 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Shanghai 201203, Peoples R China
来源：
PHARMACEUTICALS | 2022年 / 15卷 / 09期
关键词：
inflammatory bowel disease; cytokines; lymphocyte homing; LONG-TERM SAFETY; CHRONIC INTESTINAL INFLAMMATION; ACTIVE CROHNS-DISEASE; OPEN-LABEL EXTENSION; ULCERATIVE-COLITIS; MAINTENANCE THERAPY; INDUCTION THERAPY; DOUBLE-BLIND; MONOCLONAL-ANTIBODY; ANTI-TL1A ANTIBODY;
D O I：
10.3390/ph15091080
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Inflammatory bowel diseases (IBDs) are characterized by chronic inflammatory disorders that are a result of an abnormal immune response mediated by a cytokine storm and immune cell infiltration. Proinflammatory cytokine therapeutic agents, represented by TNF inhibitors, have developed rapidly over recent years and are promising options for treating IBD. Antagonizing interleukins, interferons, and Janus kinases have demonstrated their respective advantages in clinical trials and are candidates for anti-TNF therapeutic failure. Furthermore, the blockade of lymphocyte homing contributes to the excessive immune response in colitis and ameliorates inflammation and tissue damage. Factors such as integrins, selectins, and chemokines jointly coordinate the accumulation of immune cells in inflammatory regions. This review assembles the major targets and agents currently targeting proinflammatory cytokines and lymphatic trafficking to facilitate subsequent drug development.
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页数：22
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