Design, synthesis and biological activity of novel quinazolinone-based Caspase 3 inhibitors

被引:0
|
作者
Greenfield, A
Grosanu, C
Tawa, GJ
Childers, WE
Harrison, BL
Magolda, RL
Robichaud, AJ
Aulabaugh, A
Chan, H
Cowling, R
Fennel, M
Huang, XY
Hum, WT
Kapoor, B
Ling, HP
Wood, A
机构
[1] Wyeth Ayerst Res, Chem & Screening Sci, Princeton, NJ 08543 USA
[2] Wyeth Ayerst Res, Neurosci, Princeton, NJ 08543 USA
来源
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 230卷
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
318-MEDI
引用
收藏
页码:U2684 / U2684
页数:1
相关论文
共 50 条
  • [31] Design, synthesis and biological evaluation of novel spiro-quinazolinone derivatives as chitin synthase inhibitors and antifungal agents
    Du, Chuanbiao
    Yang, Xinlong
    Long, Yan
    Lang, Xueqing
    Liu, Lige
    Xu, Yajie
    Wu, Hu
    Chu, Yiwen
    Hu, Xiaolei
    Deng, Junfeng
    Ji, Qinggang
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 255
  • [32] Design, Synthesis, and Biological Activity of Novel Ornithine Decarboxylase (ODC) Inhibitors
    Schultz, Chad R.
    Aleiwi, Bilal
    Zhou, X. Edward
    Suino-Powell, Kelly
    Melcher, Karsten
    Almeida, Nuno M. S.
    Wilson, Angela K.
    Ellsworth, Edmund L.
    Bachmann, Andre S.
    JOURNAL OF MEDICINAL CHEMISTRY, 2025, 68 (05) : 5760 - 5773
  • [33] Design, Synthesis and Biological Activity Evaluation of Novel Rho Kinase Inhibitors
    Yao, Yangyang
    Liu, Xiaoyu
    Yang, Feilong
    Yang, Ying
    Yuan, Tianyi
    Fang, Lianhua
    Du, Guanhua
    Jiao, Xiaozhen
    Xie, Ping
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 38 (04) : 871 - 882
  • [34] Synthesis, Characterization, Antibacterial Evaluation, and Molecular Docking of New Quinazolinone-Based Derivatives
    Dehbi, Oussama
    Riadi, Yassine
    Geesi, Mohammed H.
    Anouar, El Hassane
    Ibnouf, Elmutasim O.
    Azzallou, Rachid
    POLYCYCLIC AROMATIC COMPOUNDS, 2023, 43 (02) : 1879 - 1887
  • [35] Novel Phthalic-Based Anticancer Tyrosine Kinase Inhibitors: Design, Synthesis and Biological Activity
    Kalinichenko, Elena
    Faryna, Aliaksandr
    Bozhok, Tatyana
    Golyakovich, Anna
    Panibrat, Alesya
    CURRENT ISSUES IN MOLECULAR BIOLOGY, 2023, 45 (03) : 1820 - 1842
  • [36] Quinazolinone-Based Anticancer Agents: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Tubulin Co-crystal Structure
    Dohle, Wolfgang
    Jourdan, Fabrice L.
    Menchon, Gregory
    Prota, Andrea E.
    Foster, Paul A.
    Mannion, Pascoe
    Hamel, Ernest
    Thomas, Mark P.
    Kasprzyk, Philip G.
    Ferrandis, Eric
    Steinmetz, Michel O.
    Leese, Mathew P.
    Potter, Barry V. L.
    JOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (03) : 1031 - 1044
  • [37] Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment
    Le, Yi
    Gan, Yiyuan
    Fu, Yihong
    Liu, Jiamin
    Li, Wen
    Zou, Xue
    Zhou, Zhixu
    Wang, Zhechao
    Ouyang, Guiping
    Yan, Longjia
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2020, 35 (01) : 555 - 564
  • [38] Design, Synthesis and Antitumor Activities of Novel Quinazolinone Derivatives as Potential EGFR Inhibitors
    Wang, Jing
    Huang, Liwei
    Chen, Xi
    Yuan, Yangchen
    Sun, Juan
    Yang, Meng
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2022, 70 (09) : 637 - 641
  • [39] Design, syntheses and biological evaluations of nonpeptidic caspase 3 inhibitors
    Kim, ES
    Yoo, SE
    Yi, KY
    Lee, S
    Noh, JS
    Jung, YS
    Kim, E
    Jeong, N
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2002, 23 (07) : 1003 - 1010
  • [40] Design, Synthesis and Molecular Docking of Novel Quinazolinone Hydrazide Derivatives as EGFR Inhibitors
    Fang, Ze-Yu
    Zhang, Yi-Heng
    Chen, Chong-Hao
    Zheng, Qi
    Lv, Peng-Cheng
    Ni, Lei-Qiang
    Sun, Juan
    Wu, Yuan-Feng
    CHEMISTRY & BIODIVERSITY, 2022, 19 (06)