Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases

被引：33
|
作者：
Sala-Rabanal, Monica [1 ,2 ]
Yurtsever, Zeynep [2 ,3 ,4 ,5 ]
Berry, Kayla N. [4 ,6 ]
Brett, Tom J. [1 ,2 ,4 ,5 ,7 ]
机构：
[1] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Ctr Invest Membrane Excitabil Dis, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Biochem Program, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA
[5] Washington Univ, Sch Med, Drug Discovery Program Pulm & Crit Care Med, St Louis, MO 63110 USA
[6] Washington Univ, Sch Med, Med Sci Training Program, St Louis, MO 63110 USA
[7] Washington Univ, Sch Med, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA
来源：
MEDIATORS OF INFLAMMATION | 2015年 / 2015卷
关键词：
BORDETELLA-PERTUSSIS INFECTION; BRONCHIAL EPITHELIAL-CELLS; ANION TRANSPORTER PENDRIN; SLC26 GENE FAMILY; MUCUS PRODUCTION; HUMAN CLCA1; FUNCTIONAL-ANALYSIS; MUCIN SECRETION; MOUSE MODELS; STAS DOMAIN;
D O I：
10.1155/2015/497387
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction. However, they also play crucial roles in contributing to the innate immune properties of mucus and mucociliary clearance. In this review, we focus on the emerging novel roles for a chloride channel regulator (CLCA1), a calcium-activated chloride channel (TMEM16A), and two chloride exchangers (SLC26A4/pendrin and SLC26A9) in chronic inflammatory airway diseases.
引用
收藏
页数：13
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