Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases

被引：33

作者：

Sala-Rabanal, Monica ^{[1
,2
]}

Yurtsever, Zeynep ^{[2
,3
,4
,5
]}

Berry, Kayla N. ^{[4
,6
]}

Brett, Tom J. ^{[1
,2
,4
,5
,7
]}

机构：

[1] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Ctr Invest Membrane Excitabil Dis, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Biochem Program, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA

[5] Washington Univ, Sch Med, Drug Discovery Program Pulm & Crit Care Med, St Louis, MO 63110 USA

[6] Washington Univ, Sch Med, Med Sci Training Program, St Louis, MO 63110 USA

[7] Washington Univ, Sch Med, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA

来源：

MEDIATORS OF INFLAMMATION | 2015年 / 2015卷

关键词：

BORDETELLA-PERTUSSIS INFECTION; BRONCHIAL EPITHELIAL-CELLS; ANION TRANSPORTER PENDRIN; SLC26 GENE FAMILY; MUCUS PRODUCTION; HUMAN CLCA1; FUNCTIONAL-ANALYSIS; MUCIN SECRETION; MOUSE MODELS; STAS DOMAIN;

D O I：

10.1155/2015/497387

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction. However, they also play crucial roles in contributing to the innate immune properties of mucus and mucociliary clearance. In this review, we focus on the emerging novel roles for a chloride channel regulator (CLCA1), a calcium-activated chloride channel (TMEM16A), and two chloride exchangers (SLC26A4/pendrin and SLC26A9) in chronic inflammatory airway diseases.

引用

页数：13

共 50 条

[31] Motile Ciliary Disorders in Chronic Airway Inflammatory Diseases: Critical Target for Interventions
Guan, Wei-jie
Peng, Yang
Zi, Xiao-xue
Tan, Kai Sen
He, Ting-ting
Zhong, Nan-shan
Wang, De Yun
CURRENT ALLERGY AND ASTHMA REPORTS, 2018, 18 (09)
[32] Clinical signs and physiopathological mechanisms of the main chronic inflammatory airway diseases of the horse
Mesnil, C.
Bureau, F.
Lekeux, P.
ANNALES DE MEDECINE VETERINAIRE, 2006, 150 (04) : 227 - 240
[33] INFLAMMATORY SPUTUM CYTOLOGY - DIAGNOSTIC AND PROGNOSTIC ASPECTS IN CHRONIC NONSPECIFIC AIRWAY DISEASES
MEDICI, TC
HERMANN, R
THERAPEUTISCHE UMSCHAU, 1977, 34 (03) : 164 - 171
[34] Neutrophils in chronic inflammatory airway diseases: can we target them and how?
Gernez, Y.
Tirouvanziam, R.
Chanez, P.
EUROPEAN RESPIRATORY JOURNAL, 2010, 35 (03) : 467 - 469
[35] IL1RAP is an emerging target in chronic airway inflammatory diseases
Kasetty, G.
Jonsson, M.
Persson, J.
Grundevik, P.
Nys, J.
Cohen, S.
Borde, A.
Birrell, M. A.
EUROPEAN RESPIRATORY JOURNAL, 2022, 60
[36] UP-REGULATING THE ENDOGENOUS NEGATIVE REGULATORS: A NOVEL THERAPEUTIC STRATEGY FOR INFLAMMATORY DISEASES
Pan, Karen
Pan, Zhixing K.
SHOCK, 2018, 49 (06): : 57 - 57
[37] Discovery of a novel BLT2 antagonist for the treatment of inflammatory airway diseases
Park, Hyejun
Harmalkar, Dipesh S.
Wei, Jun-Dong
Sun, Seunghan
Kwon, Jinsun
Park, Jin-Mi
Lee, Jae-Won
Ahn, Kyung-Seop
Han, Hyo-Kyung
Kim, Jae-Hong
Lee, Kyeong
Choi, Yongseok
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 261
[38] Novel, Potent, Inhaled Gsnor Inhibitors For Potential Treatment Of Inflammatory Airway Diseases
Kulkarni, A.
Nagarajan, M.
Banerjee, A.
Gharat, L.
Shah, D.
Chakraborti, S.
Sarkar, I.
Gudi, G.
Jadhav, S.
Khairatkar-Joshi, N.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2015, 191
[39] REGULATORY INTERACTION BETWEEN CFTR AND ORCC CHLORIDE CHANNELS IN AIRWAY EPITHELIA - ROLES FOR CYCLIC-AMP AND ATP
SCHWIEBERT, EM
EGAN, ME
GUGGINO, WB
FASEB JOURNAL, 1994, 8 (04): : A294 - A294
[40] IGFBP-6 Network in Chronic Inflammatory Airway Diseases and Lung Tumor Progression
Venuto, Santina
Daniela Coda, Anna Rita
Gonzalez-Perez, Ruperto
Laselva, Onofrio
Tolomeo, Doron
Tiziana Storlazzi, Clelia
Liso, Arcangelo
Conese, Massimo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (05)

← 1 2 3 4 5 →