Greener synthesis of ZnO and Ag-ZnO nanoparticles using Silybum marianum for diverse biomedical applications

被引：122
|
作者：
Hameed, Safia [1 ]
Khalil, Ali T. [2 ,3 ,4 ]
Ali, Muhammad [1 ]
Numan, Muhammad [1 ]
Khamlich, Saleh [3 ,4 ]
Shinwari, Zabta K. [2 ,5 ]
Maaza, Malik [2 ,4 ]
机构：
[1] Quaid I Azam Univ, Dept Biotechnol, Islamabad, Pakistan
[2] Qarshi Univ, Dept Eastern Med & Surg, Lahore, Pakistan
[3] Univ South Africa, UNESCO UNISA Africa Chair Nanosci & Nanotechnol, Coll Grad Studies, Pretoria, South Africa
[4] IThemba LABS, Nanosci African Network NANOAFNET, Mat Res Dept, Cape Town, South Africa
[5] Pakistan Acad Sci, Islamabad, Pakistan
来源：
NANOMEDICINE | 2019年 / 14卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
Ag-ZnO; antileishmanial; antimicrobial; antioxidant; enzyme inhibition; nanocomposite; nanoparticles; nanoscosmaceutical; Silybum marianum; ZnO; ZINC-OXIDE NANOPARTICLES; LEAF EXTRACT; IN-VITRO; ANTIBACTERIAL ACTIVITY; PHYTOCHEMICAL ANALYSIS; METHANOLIC EXTRACT; CANCER-CELLS; BIOSYNTHESIS; ANTIOXIDANT; NANOSTRUCTURES;
D O I：
10.2217/nnm-2018-0279
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: To investigate the physical and biological properties of Silybum marianum inspired ZnO nanoparticles (NPs), Ag-ZnO heterostructures. Experiment: Nanoparticles were characterized using ultraviolet-visible and infrared spectroscopy, x-ray diffraction, high resolution electron microscopy, zeta potential and thermo-gravimetric analysis etc. Results: Ag-ZnO-NPs indicated slightly higher antimicrobial potential then ZnO-NPs. Good antileishmanial (IC50 = 246 mu g/ml for Ag-ZnO; 341 mu g/ml for ZnO) and antioxidant potential while moderate enzyme inhibition is reported. 2, 2-Diphenyl 1-picrylhydrazyl radical scavenging of Ag-ZnO was higher relative to ZnO-NPs. Nanocosmaceutical formulation of nanoparticles indicated stable antimicrobial performance. Conclusion: Biosynthesized nanoparticles indicated interesting biological properties and should be subjected to further research to establish their pharmacological relevance.
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页码：655 / 673
页数：19
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