Magnetic Field Stimuli-Sensitive Drug Release Using a Magnetic Thermal Seed Coated with Thermal-Responsive Molecularly Imprinted Polymer

被引：37

作者：

Kubo, Takuya ^{[1
]}

Tachibana, Kaname ^{[1
]}

Naito, Toyohiro ^{[1
]}

Mukai, Sadaatsu ^{[2
]}

Akiyoshi, Kazunari ^{[2
]}

Balachandran, Jeyadevan ^{[3
]}

Otsuka, Koji ^{[1
]}

机构：

[1] Kyoto Univ, Dept Chem Mat, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, Japan

[2] Kyoto Univ, Grad Sch Engn, Dept Polymer Chem, Nishikyo Ku, Kyoto 6158510, Japan

[3] Univ Shiga Prefecture, Dept Mat Sci, 2500 Hassaka Cho, Hikone City, Shiga 5228533, Japan

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2019年 / 5卷 / 02期

基金：

日本学术振兴会;

关键词：

magnetic thermal seed; molecularly imprinted polymer; stimuli-sensitive drug release; AC magnetic field; SELECTIVE SEPARATION; NANOPARTICLES; HYDROGELS; THERAPY; METHOTREXATE; HYPERTHERMIA; MICROSPHERE; RECOGNITION; EXTRACTION; DESIGN;

D O I：

10.1021/acsbiomaterials.8b01401

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A new stimulus-responsive drug delivery system using Fe3O4 nanoparticles coated with molecularly imprinted polymer (MIP) is reported. Magnetic thermal seeds (MTS) with their size controlled between 10 and 20 nm that could generate heat under an alternate current (AC) magnetic field were modified with a thermal-responsive MIP by grafting polymerization for effective release of an anticancer drug, methotrexate (MTX). The MIP-coated MTS showed the superparamagnetic property as well as the selective adsorption ability toward MTX, and 80% of MXT adsorbed on the MIP-coated MTS was stimulus released at 60 degrees C by cleaving hydrogen bonding in the recognition sites. Finally, the MTX release from the MTX-loaded MIP-coated MTS under an AC magnetic field within 10 min was successfully demonstrated.

引用

页码：759 / 767

页数：17

共 40 条

[31] Development of a novel magnetic molecularly imprinted polymer coating using porous zeolite imidazolate framework-8 coated magnetic iron oxide as carrier for automated solid phase microextraction of estrogens in fish and pork samples
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JOURNAL OF CHROMATOGRAPHY A, 2014, 1365 : 35 - 44
[32] Selective solid-phase extraction of naproxen drug from human urine samples using molecularly imprinted polymer-coated magnetic multi-walled carbon nanotubes prior to its spectrofluorometric determination
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ANALYST, 2013, 138 (16) : 4542 - 4549
[33] Synthesis and Characterization of the Magnetic Molecularly Imprinted Polymer Nanoparticles Using N, N-bis Methacryloyl Ethylenediamine as a New Cross-linking Agent for Controlled Release of Meloxicam
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[34] Synthesis and Characterization of the Magnetic Molecularly Imprinted Polymer Nanoparticles Using N, N-bis Methacryloyl Ethylenediamine as a New Cross-linking Agent for Controlled Release of Meloxicam
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Abdouss, Majid
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APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2014, 172 (06) : 3271 - 3286
[35] pH and thermal dual-responsive poly(NIPAM-co-GMA)-coated magnetic nanoparticles via surface-initiated RAFT polymerization for controlled drug delivery
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MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2020, 108
[36] Synthesis and characterization of the core-shell magnetic molecularly imprinted polymer nanoparticles using 2-(methacrylamido)ethyl methacrylate amide as a novel cross-link agent for controlled release of betamethasone
Abdouss, Majid (majidabdouss@yahoo.com), 1600, John Wiley and Sons Inc, Postfach 10 11 61, 69451 Weinheim, Boschstrabe 12, 69469 Weinheim, Deutschland, 69469, Germany (134):
[37] Synthesis of Stimuli-Responsive Platform Based on Polyester Dendrimer Conjugated to Thermo-Sensitive Polymer Coated Nanodiamonds as Paclitaxel Drug Delivery System on MCF-7 Cell Line: An Efficient Near-Infrared Photo-Thermal Therapeutic
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JOURNAL OF POLYMERS AND THE ENVIRONMENT, 2024, 32 (06) : 2713 - 2728
[38] Reversible Drug Delivery: Thermal and pH Sensitive Composite Membrane for On-Demand Drug Delivery by Applying an Alternating Magnetic Field (Adv. Mater. Interfaces 17/2020)
Wang Y.
Boero G.
Zhang X.
Brugger J.
1600, Wiley-VCH Verlag (07):
[39] Erratum: Synthesis and characterization of the core -shell magnetic molecularly imprinted polymer nanoparticles using 2-(methacrylamido)ethyl methacrylate amide as a novel cross-link agent for controlled release of betamethasone (Journal of Applied Polymer Science)
1600, John Wiley and Sons Inc., P.O.Box 18667, Newark, NJ 07191-8667, United States (131):
[40] RETRACTED: Synthesis and Characterization of the Core-Shell Magnetic Molecularly Imprinted Polymer Nanoparticles Using 2-(Methacrylamido)ethyl Methacrylate Amide as a Novel Cross-Link Agent for Controlled Release of Betamethasone (Retracted Article)
Azodi-Deilami, Saman
Abdouss, Majid
Kordestani, Davood
JOURNAL OF APPLIED POLYMER SCIENCE, 2017, 134 (23)

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