Magnetic Field Stimuli-Sensitive Drug Release Using a Magnetic Thermal Seed Coated with Thermal-Responsive Molecularly Imprinted Polymer

被引：37
|
作者：
Kubo, Takuya [1 ]
Tachibana, Kaname [1 ]
Naito, Toyohiro [1 ]
Mukai, Sadaatsu [2 ]
Akiyoshi, Kazunari [2 ]
Balachandran, Jeyadevan [3 ]
Otsuka, Koji [1 ]
机构：
[1] Kyoto Univ, Dept Chem Mat, Grad Sch Engn, Nishikyo Ku, Kyoto 6158510, Japan
[2] Kyoto Univ, Grad Sch Engn, Dept Polymer Chem, Nishikyo Ku, Kyoto 6158510, Japan
[3] Univ Shiga Prefecture, Dept Mat Sci, 2500 Hassaka Cho, Hikone City, Shiga 5228533, Japan
来源：
ACS BIOMATERIALS SCIENCE & ENGINEERING | 2019年 / 5卷 / 02期
基金：
日本学术振兴会;
关键词：
magnetic thermal seed; molecularly imprinted polymer; stimuli-sensitive drug release; AC magnetic field; SELECTIVE SEPARATION; NANOPARTICLES; HYDROGELS; THERAPY; METHOTREXATE; HYPERTHERMIA; MICROSPHERE; RECOGNITION; EXTRACTION; DESIGN;
D O I：
10.1021/acsbiomaterials.8b01401
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
A new stimulus-responsive drug delivery system using Fe3O4 nanoparticles coated with molecularly imprinted polymer (MIP) is reported. Magnetic thermal seeds (MTS) with their size controlled between 10 and 20 nm that could generate heat under an alternate current (AC) magnetic field were modified with a thermal-responsive MIP by grafting polymerization for effective release of an anticancer drug, methotrexate (MTX). The MIP-coated MTS showed the superparamagnetic property as well as the selective adsorption ability toward MTX, and 80% of MXT adsorbed on the MIP-coated MTS was stimulus released at 60 degrees C by cleaving hydrogen bonding in the recognition sites. Finally, the MTX release from the MTX-loaded MIP-coated MTS under an AC magnetic field within 10 min was successfully demonstrated.
引用
收藏
页码：759 / 767
页数：17
相关论文
共 40 条
  • [21] Magnetic field activated drug release system based on magnetic PLGA microspheres for chemo-thermal therapy
    Fang, Kun
    Song, Lina
    Gu, Zhuxiao
    Yang, Fang
    Zhang, Yu
    Gu, Ning
    COLLOIDS AND SURFACES B-BIOINTERFACES, 2015, 136 : 712 - 720
  • [22] Thermal and pH Responsive Polymer-Tethered Multifunctional Magnetic Nanoparticles for Targeted Delivery of Anticancer Drug
    Sahoo, Banalata
    Devi, K. Sanjana P.
    Banerjee, Rakesh
    Maiti, Tapas K.
    Pramanik, Panchanan
    Dhara, Dibakar
    ACS APPLIED MATERIALS & INTERFACES, 2013, 5 (09) : 3884 - 3893
  • [23] Self-assembly behaviors of thermal- and pH- sensitive magnetic nanocarriers for stimuli-triggered release
    Chih-Yu Kuo
    Ting-Yu Liu
    Andri Hardiansyah
    Chia-Fen Lee
    Man-Sheng Wang
    Wen-Yen Chiu
    Nanoscale Research Letters, 9
  • [24] Self-assembly behaviors of thermal- and pH- sensitive magnetic nanocarriers for stimuli-triggered release
    Kuo, Chih-Yu
    Liu, Ting-Yu
    Hardiansyah, Andri
    Lee, Chia-Fen
    Wang, Man-Sheng
    Chiu, Wen-Yen
    NANOSCALE RESEARCH LETTERS, 2014, 9
  • [25] Thermal and pH Sensitive Composite Membrane for On-Demand Drug Delivery by Applying an Alternating Magnetic Field
    Wang, Ya
    Boero, Giovanni
    Zhang, Xiaosheng
    Brugger, Juergen
    ADVANCED MATERIALS INTERFACES, 2020, 7 (17)
  • [26] Sensitive and Selective Voltammetric Determination of Ciprofloxacin Using Screen-printed Electrodes Modified with Carbon Black and Magnetic-molecularly Imprinted Polymer
    Wong, Ademar
    Santos, Anderson M.
    Silva, Tiago A.
    Moraes, Fernando C.
    Fatibello-Filho, Orlando
    Sotomayor, Maria D. P. T.
    ELECTROANALYSIS, 2023, 35 (01) : 320 - 329
  • [27] Hyperthermia evaluation and drug/protein-controlled release using alternating magnetic field stimuli-responsive Mn-Zn ferrite composite particles
    Montha, Wararat
    Maneeprakorn, Weerakanya
    Tang, I-Ming
    Pon-On, Weeraphat
    RSC ADVANCES, 2020, 10 (66) : 40206 - 40214
  • [28] Morphological, thermal and drug release studies of poly (methacrylic acid)-based molecularly imprinted polymer nanoparticles immobilized in electrospun poly (ε-caprolactone) nanofibers as dexamethasone delivery system
    Payam Zahedi
    Mahshid Fallah-Darrehchi
    Shima Ahmadi Nadoushan
    Robabeh Aeinehvand
    Lida Bagheri
    Mohammad Najafi
    Korean Journal of Chemical Engineering, 2017, 34 : 2110 - 2118
  • [29] Morphological, thermal and drug release studies of poly (methacrylic acid)-based molecularly imprinted polymer nanoparticles immobilized in electrospun poly (ε-caprolactone) nanofibers as dexamethasone delivery system
    Zahedi, Payam
    Fallah-Darrehchi, Mahshid
    Nadoushan, Shima Ahmadi
    Aeinehvand, Robabeh
    Bagheri, Lida
    Najafi, Mohammad
    KOREAN JOURNAL OF CHEMICAL ENGINEERING, 2017, 34 (07) : 2110 - 2118
  • [30] Synthesis of poly(2-hydroxyethyl methacrylate)-based molecularly imprinted polymer nanoparticles containing timolol maleate: morphological, thermal, and drug release along with cell biocompatibility studies
    Aeinehvand, Robabeh
    Zahedi, Payam
    Kashani-Rahimi, Shahab
    Fallah-Darrehchi, Mahshid
    Shamsi, Mohammad
    POLYMERS FOR ADVANCED TECHNOLOGIES, 2017, 28 (07) : 828 - 841
1234