Stem cell-based cell therapy for neuroprotection in stroke: A review

被引:34
|
作者
Rikhtegar, Reza [1 ]
Yousefi, Mehdi [2 ,3 ]
Dolati, Sanam [1 ,4 ]
Kasmaei, Hosein Delavar [5 ]
Charsouei, Saeid [1 ]
Nouri, Mohammad [2 ]
Shakouri, Seyed Kazem [1 ,6 ]
机构
[1] Tabriz Univ Med Sci, Aging Res Inst, Tabriz, Iran
[2] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran
[3] Tabriz Univ Med Sci, Sch Med, Dept Immunol, Tabriz, Iran
[4] Tabriz Univ Med Sci, Students Res Comm, Tabriz, Iran
[5] Shahid Beheshti Univ Med Sci, Shohada E Tajrish Hosp, Dept Neurol, Tehran, Iran
[6] Tabriz Univ Med Sci, Phys Med & Rehabil Res Ctr, Tabriz, Iran
关键词
clinical trials; ischemic stroke; stem cell therapy; ACUTE ISCHEMIC-STROKE; UMBILICAL-CORD BLOOD; TISSUE-PLASMINOGEN ACTIVATOR; MESENCHYMAL STROMAL CELLS; MARROW MONONUCLEAR-CELLS; FOCAL CEREBRAL-ISCHEMIA; ADULT PROGENITOR CELLS; PLATELET-RICH PLASMA; CLINICAL-TRIALS; DOUBLE-BLIND;
D O I
10.1002/jcb.28207
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Neurological disorders, such as stroke, are triggered by a loss of neurons and glial cells. Ischemic stroke remains a substantial problem for industrialized countries. Over the previous few decades our understanding about the pathophysiology of stroke has enhanced, nevertheless, more awareness is required to advance the field of stroke recovery. Existing therapies are incapable to adequately relief the disease outcome and are not appropriate to all patients. Meanwhile, the majority of patients continue to show neurological deficits even subsequent effective thrombolysis, recuperative therapies are immediately required that stimulate brain remodeling and repair once stroke damage has happened. Cell therapy is emergent as a hopeful new modality for increasing neurological recovery in ischemic stroke. Numerous types of stem cells from various sources have been identified and their possibility and efficiency for the treatment of stroke have been investigated. Stem cell therapy in patients with stroke using adult stem cells have been first practiced in clinical trials since 15 years ago. Even though stem cells have revealed a hopeful role in ischemic stroke in investigational studies besides early clinical pilot studies, cellular therapy in human is still at a primary stage. In this review, we summarize the types of stem cells, various delivery routes, and clinical application of stem cell-based therapy for stroke treatment.
引用
收藏
页码:8849 / 8862
页数:14
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