Mesenchymal Stem Cell-Based Therapy

被引：98
|
作者：
Mundra, Vaibhav [1 ]
Gerling, Ivan C. [2 ]
Mahato, Ram I. [1 ]
机构：
[1] Univ Tennessee, Hlth Sci Ctr, Dept Pharmaceut Sci, Memphis, TN 38103 USA
[2] Univ Tennessee, Hlth Sci Ctr, Dept Endocrinol, Memphis, TN 38103 USA
来源：
MOLECULAR PHARMACEUTICS | 2013年 / 10卷 / 01期
基金：
美国国家卫生研究院;
关键词：
mesenchymal stem cells; immunomodulation; islet transplantation; gene delivery; biomaterials; MARROW STROMAL CELLS; INSULIN-PRODUCING CELLS; ENDOTHELIAL GROWTH-FACTOR; VERSUS-HOST-DISEASE; BONE-MARROW; IN-VITRO; NEURONAL CELLS; GRAFT FUNCTION; GENE DELIVERY; T-CELLS;
D O I：
10.1021/mp3005148
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Mesenchymal stem cells (MSCs) are multipotent adult stem cells which have self-renewal capacity and differentiation potential into several mesenchyrnal lineages including bones, cartilages, adipose tissues and tendons. MSCs may repair tissue injuries and prevent immune cell activation and proliferation. Immunomodulation and secretion of growth factors by MSCs have led to realizing the true potential of MSC-based cell therapy. The use of MSCs as immunomodulators has been explored in cell/organ transplant, tissue repair, autoimmune diseases, and prevention of graft vs host disease (GVHD). This review focuses on the clinical applications of MSC-based cell therapy, with particular emphasis on islet transplantation for treating type I diabetes.
引用
收藏
页码：77 / 89
页数：13
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