Mesenchymal Stem Cell-Based Therapy

被引：98
|
作者：
Mundra, Vaibhav [1 ]
Gerling, Ivan C. [2 ]
Mahato, Ram I. [1 ]
机构：
[1] Univ Tennessee, Hlth Sci Ctr, Dept Pharmaceut Sci, Memphis, TN 38103 USA
[2] Univ Tennessee, Hlth Sci Ctr, Dept Endocrinol, Memphis, TN 38103 USA
来源：
MOLECULAR PHARMACEUTICS | 2013年 / 10卷 / 01期
基金：
美国国家卫生研究院;
关键词：
mesenchymal stem cells; immunomodulation; islet transplantation; gene delivery; biomaterials; MARROW STROMAL CELLS; INSULIN-PRODUCING CELLS; ENDOTHELIAL GROWTH-FACTOR; VERSUS-HOST-DISEASE; BONE-MARROW; IN-VITRO; NEURONAL CELLS; GRAFT FUNCTION; GENE DELIVERY; T-CELLS;
D O I：
10.1021/mp3005148
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Mesenchymal stem cells (MSCs) are multipotent adult stem cells which have self-renewal capacity and differentiation potential into several mesenchyrnal lineages including bones, cartilages, adipose tissues and tendons. MSCs may repair tissue injuries and prevent immune cell activation and proliferation. Immunomodulation and secretion of growth factors by MSCs have led to realizing the true potential of MSC-based cell therapy. The use of MSCs as immunomodulators has been explored in cell/organ transplant, tissue repair, autoimmune diseases, and prevention of graft vs host disease (GVHD). This review focuses on the clinical applications of MSC-based cell therapy, with particular emphasis on islet transplantation for treating type I diabetes.
引用
收藏
页码：77 / 89
页数：13
相关论文
共 50 条
  • [11] Mesenchymal stem cell-based gene therapy for erectile dysfunction
    J H Kim
    H J Lee
    Y S Song
    [J]. International Journal of Impotence Research, 2016, 28 : 81 - 87
  • [12] Mesenchymal stem cell-based therapy for burn wound healing
    Wang, Mingyao
    Xu, Xinxuan
    Lei, Xiongxin
    Tan, Jie
    Xie, Huiqi
    [J]. BURNS & TRAUMA, 2021, 9
  • [13] Mesenchymal stem cell-based therapy for cartilage repair: a review
    Hideyuki Koga
    Lars Engebretsen
    Jan E. Brinchmann
    Takeshi Muneta
    Ichiro Sekiya
    [J]. Knee Surgery, Sports Traumatology, Arthroscopy, 2009, 17 : 1289 - 1297
  • [14] The Potential Role of Microvesicles in Mesenchymal Stem Cell-Based Therapy
    Huang, Yong-Can
    Parolini, Ornella
    Deng, Li
    [J]. STEM CELLS AND DEVELOPMENT, 2013, 22 (06) : 841 - 844
  • [15] Mesenchymal stem cell-based therapy for cartilage repair: a review
    Koga, Hideyuki
    Engebretsen, Lars
    Brinchmann, Jan E.
    Muneta, Takeshi
    Sekiya, Ichiro
    [J]. KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 2009, 17 (11) : 1289 - 1297
  • [16] Osteoporosis: the current status of mesenchymal stem cell-based therapy
    Jitrada Phetfong
    Tanwarat Sanvoranart
    Kuneerat Nartprayut
    Natakarn Nimsanor
    Kanokwan Seenprachawong
    Virapong Prachayasittikul
    Aungkura Supokawej
    [J]. Cellular & Molecular Biology Letters, 2016, 21
  • [17] Update on mesenchymal stem cell-based therapy in lupus and scleroderma
    Audrey Cras
    Dominique Farge
    Thierry Carmoi
    Jean-Jacques Lataillade
    Dan Dan Wang
    Lingyun Sun
    [J]. Arthritis Research & Therapy, 17
  • [18] Mesenchymal Stem Cell-based Therapy for Type 1 Diabetes
    Wu, Hao
    Mahato, Ram I.
    [J]. DISCOVERY MEDICINE, 2014, 17 (93) : 139 - 143
  • [19] Mesenchymal stem cells: Cell-based reconstructive therapy in orthopedics
    Caplan, AI
    [J]. TISSUE ENGINEERING, 2005, 11 (7-8): : 1198 - 1211
  • [20] Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease
    Lai, Ruenn Chai
    Chen, Tian Sheng
    Lim, Sai Kiang
    [J]. REGENERATIVE MEDICINE, 2011, 6 (04) : 481 - 492
12345