Characterization of natural killer cells in paired CSF and blood samples during neuroinflammation

被引：24
|
作者：
Hamann, Isabell [1 ,2 ]
Doerr, Jan [2 ,3 ]
Glumm, Robert [2 ,3 ]
Chanvillard, Coralie [1 ,2 ]
Janssen, Antonia [1 ,2 ]
Millward, Jason M. [1 ,2 ]
Paul, Friedemann [1 ,2 ,3 ]
Ransohoff, Richard M. [4 ]
Infante-Duarte, Carmen [1 ,2 ]
机构：
[1] Expt & Clin Res Ctr, Berlin, Germany
[2] Charite, Clin & Expt Multiple Sclerosis Res Ctr, D-10117 Berlin, Germany
[3] Charite, NeuroCure Clin Res Ctr, D-10117 Berlin, Germany
[4] Cleveland Clin, Lerner Res Inst, Neuroinflammat Res Ctr, Cleveland, OH 44106 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 254卷 / 1-2期
关键词：
Natural killer cells; CSF; NK cell maturation; Multiple sclerosis; Neuroinflammation; CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS; NK-CELLS; SUBSETS;
D O I：
10.1016/j.jneuroim.2012.08.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Natural killer (NM) cells from paired CSF and blood samples of patients with multiple sclerosis (MS), other neuroinflammatory diseases (IND), and non-inflammatory neurological diseases (NIND) were characterized using flow cytometry. NM cell frequency in CSF was overall decreased compared to blood, particularly in MS patients. In contrast to blood NM cells, during neuroinflammation, CSF NM cells display an immature phenotype with bright expression of CD56 and CD27 and reduced CX3CR1 expression. Our findings suggest that, as for central memory T cells, CSF may represent an intermediary compartment for NM cell trafficking and differentiation before entering the CNS parenchyma. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：165 / 169
页数：5
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