Characterization of natural killer cells in paired CSF and blood samples during neuroinflammation

被引：24

作者：

Hamann, Isabell ^{[1
,2
]}

Doerr, Jan ^{[2
,3
]}

Glumm, Robert ^{[2
,3
]}

Chanvillard, Coralie ^{[1
,2
]}

Janssen, Antonia ^{[1
,2
]}

Millward, Jason M. ^{[1
,2
]}

Paul, Friedemann ^{[1
,2
,3
]}

Ransohoff, Richard M. ^{[4
]}

Infante-Duarte, Carmen ^{[1
,2
]}

机构：

[1] Expt & Clin Res Ctr, Berlin, Germany

[2] Charite, Clin & Expt Multiple Sclerosis Res Ctr, D-10117 Berlin, Germany

[3] Charite, NeuroCure Clin Res Ctr, D-10117 Berlin, Germany

[4] Cleveland Clin, Lerner Res Inst, Neuroinflammat Res Ctr, Cleveland, OH 44106 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 254卷 / 1-2期

关键词：

Natural killer cells; CSF; NK cell maturation; Multiple sclerosis; Neuroinflammation; CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS; NK-CELLS; SUBSETS;

D O I：

10.1016/j.jneuroim.2012.08.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NM) cells from paired CSF and blood samples of patients with multiple sclerosis (MS), other neuroinflammatory diseases (IND), and non-inflammatory neurological diseases (NIND) were characterized using flow cytometry. NM cell frequency in CSF was overall decreased compared to blood, particularly in MS patients. In contrast to blood NM cells, during neuroinflammation, CSF NM cells display an immature phenotype with bright expression of CD56 and CD27 and reduced CX3CR1 expression. Our findings suggest that, as for central memory T cells, CSF may represent an intermediary compartment for NM cell trafficking and differentiation before entering the CNS parenchyma. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：165 / 169

页数：5

共 50 条

[21] On blood and tissue-resident natural killer cells
Narni-Mancinelli, Emilie
Berruyer, Carole
Vivier, Eric
IMMUNITY, 2024, 57 (01)
[22] Differentiation stage of cord blood natural killer cells
Dalle, JH
Wagner, E
Blagdon, M
Champagne, J
Champagne, M
Menezes, J
Duval, M
EXPERIMENTAL HEMATOLOGY, 2003, 31 (07) : 195 - 195
[23] Cord blood natural killer T (NKT) cells
Dalle, JH
Menezes, J
Champagne, M
Michel, D
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2004, 10 (02) : 57 - 57
[24] NATURAL KILLER CELLS HARNESSED TO FIGHT BLOOD CANCER
不详
NATURE, 2024, 626 (7997) : 11 - 11
[25] Multifaceted characterization of the biological and transcriptomic signatures of natural killer cells derived from cord blood and placental blood
Haibo Gao
Min Liu
Yawei Zhang
Leisheng Zhang
Baoguo Xie
Cancer Cell International, 22
[26] Multifaceted characterization of the biological and transcriptomic signatures of natural killer cells derived from cord blood and placental blood
Gao, Haibo
Liu, Min
Zhang, Yawei
Zhang, Leisheng
Xie, Baoguo
CANCER CELL INTERNATIONAL, 2022, 22 (01)
[27] PHENOTYPIC CHARACTERIZATION OF NATURAL KILLER CELLS AND RECEPTORS IN SPONDYLOARTHRITIS
Chan, A. T. Y.
Kollnberger, S.
McMichael, A.
Bowness, P.
RHEUMATOLOGY, 2004, 43 : 128 - 128
[28] Characterization of circulating Natural Killer cells in Systemic Sclerosis
Carvalheiro, H.
Lemos, M.
Carvalheiro, T.
Salvador, M. J.
Da Silva, J. A.
Paiva, A.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2021, 51 : 175 - 175
[29] CHARACTERIZATION OF NATURAL KILLER (NK) CELLS AND KILLER (K)-CELLS IN HUMAN-BLOOD - DISCRIMINATION BETWEEN NK AND K-CELL ACTIVITIES
BOLHUIS, RLH
SCHUIT, HRE
NOOYEN, AM
RONTELTAP, CPM
EUROPEAN JOURNAL OF IMMUNOLOGY, 1978, 8 (10) : 731 - 740
[30] Characterization of Circulating Natural Killer Cells in Neotropical Primates
Carville, Angela
Evans, Tristan I.
Reeves, R. Keith
PLOS ONE, 2013, 8 (11):

← 1 2 3 4 5 →