A 14-Membered Macrolide and Isocoumarin Derivatives from the Cultured Lichen Mycobionts of Graphis vestitoides

被引：13

作者：

Le, Duy Hoang ^{[1
]}

Takenaka, Yukiko ^{[1
]}

Hamada, Nobuo ^{[2
]}

Miyawaki, Hiromi ^{[3
]}

Tanahashi, Takao ^{[1
]}

机构：

[1] Kobe Pharmaceut Univ, Higashinada Ku, Kobe, Hyogo 6588558, Japan

[2] Osaka City Inst Publ Hlth & Environm Sci, Tennouji Ku, Osaka 5430026, Japan

[3] Saga Univ, Fac Culture & Educ, Saga 8408502, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2013年 / 61卷 / 03期

关键词：

Graphis vestitoides; lichen; mycobiont; 14-membered macrolide; isocoumarin; ABSOLUTE-CONFIGURATION; METABOLITE; SCRIPTA; SP;

D O I：

10.1248/cpb.c12-00853

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Spore-derived mycobionts of the crustose lichen Graphis vestitoides collected in Vietnam were cultivated on a malt-yeast extract medium supplemented with 10% sucrose. The investigation of their metabolites resulted in isolation of a novel 14-membered macrolide and a new isocoumarin, together with five known isocoumarin derivatives. Their structures were determined by spectroscopic and chemical means. This is the first instance of isolation of a 14-membered macrolide from a lichen mycobiont.

引用

页码：358 / 362

页数：5

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