A 14-Membered Macrolide and Isocoumarin Derivatives from the Cultured Lichen Mycobionts of Graphis vestitoides

被引：13

作者：

Le, Duy Hoang ^{[1
]}

Takenaka, Yukiko ^{[1
]}

Hamada, Nobuo ^{[2
]}

Miyawaki, Hiromi ^{[3
]}

Tanahashi, Takao ^{[1
]}

机构：

[1] Kobe Pharmaceut Univ, Higashinada Ku, Kobe, Hyogo 6588558, Japan

[2] Osaka City Inst Publ Hlth & Environm Sci, Tennouji Ku, Osaka 5430026, Japan

[3] Saga Univ, Fac Culture & Educ, Saga 8408502, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2013年 / 61卷 / 03期

关键词：

Graphis vestitoides; lichen; mycobiont; 14-membered macrolide; isocoumarin; ABSOLUTE-CONFIGURATION; METABOLITE; SCRIPTA; SP;

D O I：

10.1248/cpb.c12-00853

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Spore-derived mycobionts of the crustose lichen Graphis vestitoides collected in Vietnam were cultivated on a malt-yeast extract medium supplemented with 10% sucrose. The investigation of their metabolites resulted in isolation of a novel 14-membered macrolide and a new isocoumarin, together with five known isocoumarin derivatives. Their structures were determined by spectroscopic and chemical means. This is the first instance of isolation of a 14-membered macrolide from a lichen mycobiont.

引用

页码：358 / 362

页数：5

共 50 条

[41] 3,4-DIHYDRO-2H,5H-PYRANO[3,2-c]CHROMENE AND BENZOPHENONE DERIVATIVES FROM CULTURED LICHEN MYCOBIONTS OF VIETNAMESE GRAPHIS SP.
Takenaka, Yukiko
Taguchi, Shota
Duy Hoang Le
Hamada, Nobuo
Tanahashi, Takao
[J]. HETEROCYCLES, 2013, 87 (12) : 2651 - 2657
[42] Three isocoumarins and a benzofuran from the cultured lichen mycobionts of Pyrenula sp.
Takenaka, Y
Tanahashi, T
Nagakura, N
Itoh, A
Hamada, N
[J]. PHYTOCHEMISTRY, 2004, 65 (23) : 3119 - 3123
[43] Inhibitory Effects of 14-Membered Ring Macrolide Antibiotics on Bleomycin-Induced Acute Lung Injury
M. Kawashima
J. Yatsunami
Y. Fukuno
M. Nagata
M. Tominaga
S. Hayashi
[J]. Lung, 2002, 180 : 73 - 89
[44] Effect of 14-membered ring macrolide compounds on rat leucocyte chemotaxis and the structure-activity relationships
Oohori, M
Otoguro, K
Sunazuka, T
Kunihiko, S
Iwai, Y
Omura, S
[J]. JOURNAL OF ANTIBIOTICS, 2000, 53 (10): : 1219 - 1222
[45] Inhibitory effects of 14-membered ring macrolide antibiotics on bleomycin-induced acute lung injury
Kawashima, M
Yatsunami, J
Fukuno, Y
Nagata, M
Tominaga, M
Hayashi, S
[J]. LUNG, 2002, 180 (02) : 73 - 89
[46] Eremophilane-type sesquiterpenes from cultured lichen mycobionts of Sarcographa tricosa
Le, Duy Hoang
Takenaka, Yukiko
Hamada, Nobuo
Tanahashi, Takao
[J]. PHYTOCHEMISTRY, 2013, 91 : 242 - 248
[47] Lichen secondary metabolites from the cultured lichen mycobionts of Teloschistes chrysophthalmus and Ramalina celastri and their antiviral activities
Fazio, Alejandra T.
Adler, Monica T.
Bertoni, Maria D.
Sepulveda, Claudia S.
Damonte, Elsa B.
Maier, Marta S.
[J]. ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES, 2007, 62 (7-8): : 543 - 549
[48] A new 14-membered cyclopeptide alkaloid from Zizyphus oxyphylla
Inayat-Ur-Rahman
Khan, Murad Ali
Arfan, M.
Akhtar, Gul
Khan, Lajber
Ahmad, Viqar Uddin
[J]. NATURAL PRODUCT RESEARCH, 2007, 21 (03) : 243 - 253
[49] SECONDARY METABOLITES FROM ISOLATED LICHEN MYCOBIONTS CULTURED UNDER DIFFERENT OSMOTIC CONDITIONS
HAMADA, N
MIYAGAWA, H
[J]. LICHENOLOGIST, 1995, 27 : 201 - 205
[50] C-13 SPIN-LATTICE RELAXATION-TIMES OF MEGALOMICINS, 14-MEMBERED MACROLIDE ANTIBIOTICS
PUAR, MS
BRAMBILLA, R
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1980, (12): : 1847 - 1849

← 1 2 3 4 5 →