NEW MACROLIDE ANTIBIOTICS - SYNTHESIS OF A 14-MEMBERED AZALIDE

被引：19
|
作者：
JONES, AB
机构：
[1] Merck Research Laboratories, Rahway, New Jersey 07065, R50G-236
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 16期
关键词：
D O I：
10.1021/jo00042a011
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first example of a 14-membered azalide antibiotic (5) has been prepared. The key steps are sequential oxidative cleavage processes converting furanone 12 to aldehyde 14 and the subsequent reductive rearrangement of oxime 15 to amine 20.
引用
收藏
页码：4361 / 4367
页数：7
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