In Vivo Anti-inflammatory Activity of Some Naturally Occurring O- and N-Prenyl Secondary Metabolites

被引：0
|
作者：
Epifano, Francesco [1 ]
Genovese, Salvatore [1 ]
Fiorito, Serena [1 ]
della Loggia, Roberto [2 ]
Tubaro, Aurelia [2 ]
Sosa, Silvio [2 ]
机构：
[1] Univ G dAnnunzio, Dept Pharm, I-66100 Chieti, CH, Italy
[2] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy
来源：
NATURAL PRODUCT COMMUNICATIONS | 2014年 / 9卷 / 01期
关键词：
Anti-inflammatory activity; Azoprenylated secondary metabolites; Oxyprenylated secondary metabolites; Rutaceae;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of O- and N-prenyl secondary metabolites of insect, fungal, and plant origin have been evaluated for their topical anti-inflammatory activity using the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds revealed an effect (ID50 = 0.31 divided by 40.56 mu mol/cm(2)) comparable with that of the reference non-steroidal anti-inflammatory drug indomethacin (ID50 = 0.23 mu mol/cm(2)).
引用
收藏
页码：85 / 86
页数：2
相关论文
共 50 条
  • [41] Evaluation of In Vitro Biological Activity of O-Alkylated Hydroxamic Derivatives of Some Nonsteroidal Anti-inflammatory Drugs
    Pavelic, Sandra Kraljevic
    Sedic, Mirela
    Poznic, Miroslav
    Rajic, Zrinka
    Zorc, Branka
    Pavelic, Kresimir
    Balzarini, Jan
    Mintas, Mladen
    ANTICANCER RESEARCH, 2010, 30 (10) : 3987 - 3994
  • [42] Discovery of naphthyl-N-acylhydrazone p38 MAPK inhibitors with in vivo anti-inflammatory and anti-TNF- activity
    Freitas, Rosana H. C. N.
    Cordeiro, Natalia M.
    Carvalho, Patricia R.
    Alves, Marina A.
    Guedes, Isabella A.
    Valerio, Tayna S.
    Dardenne, Laurent E.
    Lima, Lidia M.
    Barreiro, Eliezer J.
    Fernandes, Patricia D.
    Fraga, Carlos A. M.
    CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 91 (02) : 391 - 397
  • [43] Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of some new 4,6-dimethoxy-5-(heterocycles)benzofuran starting from naturally occurring visnagin
    El-Sawy, E. R.
    Ebaid, M. S.
    Abo-Salem, H. M.
    Al-Sehemi, A. G.
    Mandour, A. H.
    ARABIAN JOURNAL OF CHEMISTRY, 2014, 7 (06) : 914 - 923
  • [44] A Novel Naturally Occurring Salicylic Acid Analogue Acts as an Anti-Inflammatory Agent by Inhibiting Nuclear Factor-kappaB Activity in RAW264.7 Macrophages
    Zhang, Tiantai
    Sun, Lan
    Liu, Rui
    Zhang, Dan
    Lan, Xi
    Huang, Chao
    Xin, Wenyu
    Wang, Chao
    Zhang, Dongming
    Du, Guanhua
    MOLECULAR PHARMACEUTICS, 2012, 9 (03) : 671 - 677
  • [45] Anti-inflammatory activity of some potassium salts of N,N-disubstituted 4-aminoazobenzenesulfonic acids in rat adjuvant arthritis
    Kazemekaite, Maryte
    Leonaviciene, Laima
    Bradunaite, Ruta
    Staniulyte, Zita
    Palaima, Algirdas
    Razumas, Valdemaras
    ARCHIVES OF PHARMACAL RESEARCH, 2008, 31 (06) : 736 - 741
  • [46] Anti-inflammatory activity of some potassium salts of N,N-disubstituted 4-aminoazobenzenesulfonic acids in rat adjuvant arthritis
    Maryte Kazemekaite
    Laima Leonaviciene
    Ruta Bradunaite
    Zita Staniulyte
    Algirdas Palaima
    Valdemaras Razumas
    Archives of Pharmacal Research, 2008, 31 : 736 - 741
  • [47] Enhancement of Anti-Inflammatory Activity of Aloe vera Adventitious Root Extracts through the Alteration of Primary and Secondary Metabolites via Salicylic Acid Elicitation
    Lee, Yun Sun
    Ju, Hyun Kyoung
    Kim, Yeon Jeong
    Lim, Tae-Gyu
    Uddin, Md Romij
    Kim, Yeon Bok
    Baek, Jin Hong
    Kwon, Sung Won
    Lee, Ki Won
    Seo, Hak Soo
    Park, Sang Un
    Yang, Tae-Jin
    PLOS ONE, 2013, 8 (12):
  • [48] In Vitro and In Vivo Anti-Inflammatory Activity of 17-O-Acetylacuminolide through the Inhibition of Cytokines, NF-κB Translocation and IKKβ Activity
    Achoui, Mouna
    Appleton, David
    Abdulla, Mahmood Ameen
    Awang, Khalijah
    Mohd, Mustafa Ali
    Mustafa, Mohd Rais
    PLOS ONE, 2010, 5 (12):
  • [49] Anti-inflammatory activity of halogenated secondary metabolites of Laurencia snackeyi (Weber-van Bosse) Masuda in LPS-stimulated RAW 264.7 macrophages
    Charles Santhanaraju Vairappan
    Takashi Kamada
    Won-Woo Lee
    You-Jin Jeon
    Journal of Applied Phycology, 2013, 25 : 1805 - 1813
  • [50] Anti-inflammatory activity of halogenated secondary metabolites of Laurencia snackeyi (Weber-van Bosse) Masuda in LPS-stimulated RAW 264.7 macrophages
    Vairappan, Charles Santhanaraju
    Kamada, Takashi
    Lee, Won-Woo
    Jeon, You-Jin
    JOURNAL OF APPLIED PHYCOLOGY, 2013, 25 (06) : 1805 - 1813
12345