In Vivo Anti-inflammatory Activity of Some Naturally Occurring O- and N-Prenyl Secondary Metabolites

被引：0

作者：

Epifano, Francesco ^{[1
]}

Genovese, Salvatore ^{[1
]}

Fiorito, Serena ^{[1
]}

della Loggia, Roberto ^{[2
]}

Tubaro, Aurelia ^{[2
]}

Sosa, Silvio ^{[2
]}

机构：

[1] Univ G dAnnunzio, Dept Pharm, I-66100 Chieti, CH, Italy

[2] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy

来源：

NATURAL PRODUCT COMMUNICATIONS | 2014年 / 9卷 / 01期

关键词：

Anti-inflammatory activity; Azoprenylated secondary metabolites; Oxyprenylated secondary metabolites; Rutaceae;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of O- and N-prenyl secondary metabolites of insect, fungal, and plant origin have been evaluated for their topical anti-inflammatory activity using the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds revealed an effect (ID50 = 0.31 divided by 40.56 mu mol/cm(2)) comparable with that of the reference non-steroidal anti-inflammatory drug indomethacin (ID50 = 0.23 mu mol/cm(2)).

引用

页码：85 / 86

页数：2

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