In Vivo Anti-inflammatory Activity of Some Naturally Occurring O- and N-Prenyl Secondary Metabolites

被引：0
|
作者：
Epifano, Francesco [1 ]
Genovese, Salvatore [1 ]
Fiorito, Serena [1 ]
della Loggia, Roberto [2 ]
Tubaro, Aurelia [2 ]
Sosa, Silvio [2 ]
机构：
[1] Univ G dAnnunzio, Dept Pharm, I-66100 Chieti, CH, Italy
[2] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy
来源：
NATURAL PRODUCT COMMUNICATIONS | 2014年 / 9卷 / 01期
关键词：
Anti-inflammatory activity; Azoprenylated secondary metabolites; Oxyprenylated secondary metabolites; Rutaceae;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of O- and N-prenyl secondary metabolites of insect, fungal, and plant origin have been evaluated for their topical anti-inflammatory activity using the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds revealed an effect (ID50 = 0.31 divided by 40.56 mu mol/cm(2)) comparable with that of the reference non-steroidal anti-inflammatory drug indomethacin (ID50 = 0.23 mu mol/cm(2)).
引用
收藏
页码：85 / 86
页数：2
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