Anti-Inflammatory Activity of New Series of 1,4-Dihydropyridine Derivatives

被引：15

作者：

Idhayadhulla, A. ^{[1
]}

Kumar, R. Surendra ^{[1
]}

Nasser, A. Jamal Abdul ^{[1
]}

Kavimani, S. ^{[2
]}

Indhumathy, S. ^{[2
]}

机构：

[1] Jamal Mohamed Coll, PG & Res Dept Chem, Tiruchirappalli 620020, Tamil Nadu, India

[2] Mother Theresa Postgrad & Res Inst Hlth Sci, Dept Pharmacol, Poduchary 605006, India

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2015年 / 49卷 / 07期

关键词：

1,4-dihydropyridine; thiosemicarzide; condensation; anti-inflammatory activity; CALCIUM; COMPLEXES;

D O I：

10.1007/s11094-015-1305-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aseries of 1,4-dihydropyridine derivatives (1a - 1g) were prepared by multicomponent condensation reaction of ethylchloroacetate, 4-substituted benzaldehyde, and ammonium hydroxide as starting materials. A new series of dihydrazine carbothioamides (2a - 2g) were prepared by condensation of compounds 1a - 1g with thiosemicarbazide. The structures of synthesized compounds were confirmed by IR and 1H-NMR spectroscopy and elemental analysis. Compounds 1a - g and 2a - 2g were tested for anti-inflammatory activity on Swiss albino rats.

引用

页码：463 / 466

页数：4

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