Recent advances in hydrogel based drug delivery systems for the human body

被引:375
|
作者
Vashist, Arti [1 ]
Vashist, Atul [2 ]
Gupta, Y. K. [3 ]
Ahmad, Sharif [1 ]
机构
[1] Jamia Millia Islamia, Dept Chem, Mat Res Lab, New Delhi 110025, India
[2] All India Inst Med Sci, Dept Biotechnol, New Delhi 110029, India
[3] All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India
关键词
PH-RESPONSIVE HYDROGELS; IN-VITRO; SUPRAMOLECULAR HYDROGELS; NANOCOMPOSITE HYDROGELS; CHITOSAN MICROSPHERES; SENSITIVE HYDROGEL; CELL ENCAPSULATION; CONTROLLED-RELEASE; SUSTAINED-RELEASE; GLYCOL) HYDROGEL;
D O I
10.1039/c3tb21016b
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
The upsurge in the need of targeted controlled drug delivery ( TCDD) has led to the invention of remarkable biomaterials with improved biocompatibility and biodegradability. In recent years, "Smart Polymers" have emerged as a potential candidate, competing with the existing hydrogel systems used for controlled drug delivery. This article is an effort to highlight the diverse applications of hydrogels for revolutionizing the present research on drug delivery systems. This article summarizes the role of hydrogels as delivery vehicles for drugs used in various disorders related to the brain and other distinct parts of the human body. The clinical application and toxicological aspects of hydrogels are also highlighted. Their potential for diagnostics and various therapeutic interventions against tuberculosis have been reviewed. In addition, the limitations and future prospectives in the development of biopolymeric hydrogels are discussed.
引用
收藏
页码:147 / 166
页数:20
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