Ligand binding by repeat proteins: natural and designed

被引：97
|
作者：
Grove, Tijana Z. [1 ]
Cortajarena, Aitziber L. [1 ]
Regan, Lynne [1 ,2 ]
机构：
[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA
[2] Yale Univ, Dept Chem, New Haven, CT 06520 USA
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 2008年 / 18卷 / 04期
关键词：
D O I：
10.1016/j.sbi.2008.05.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Repeat proteins contain tandem arrays of small structural motifs. As a consequence of this architecture, they adopt non-globular, extended structures that present large, highly specific surfaces for ligand binding. Here we discuss recent advances toward understanding the functional role of this unique modular architecture. We showcase specific examples of natural repeat proteins interacting with diverse ligands and also present examples of designed repeat protein-ligand interactions.
引用
收藏
页码：507 / 515
页数：9
相关论文
共 50 条
  • [31] A recipe for ligand-binding proteins
    Giovanna Ghirlanda
    Nature, 2013, 501 : 177 - 178
  • [32] Specific targeting of human caspases using designed ankyrin repeat proteins
    Fluetsch, Andreas
    Schroeder, Thilo
    Barandun, Jonas
    Ackermann, Rafael
    Buehlmann, Martin
    Gruetter, Markus G.
    BIOLOGICAL CHEMISTRY, 2014, 395 (10) : 1243 - 1252
  • [33] DESIGNED ANKYRIN REPEAT PROTEINS AS NOVEL BINDERS FOR ULTRASOUND MOLECULAR IMAGING
    Kosareva, Alexandra
    Punjabi, Mukesh
    Ochoa-Espinosa, Amanda
    Xu, Lifen
    Schaefer, Jonas, V
    Dreier, Birgit
    Pluckthun, Andreas
    Kaufmann, Beat A.
    ULTRASOUND IN MEDICINE AND BIOLOGY, 2021, 47 (09): : 2664 - 2675
  • [34] Structure-based optimization of designed Armadillo-repeat proteins
    Madhurantakam, Chaithanya
    Varadamsetty, Gautham
    Gruetter, Markus G.
    Plueckthun, Andreas
    Mittl, Peer R. E.
    PROTEIN SCIENCE, 2012, 21 (07) : 1015 - 1028
  • [35] Designed armadillo repeat proteins: Development of a modular peptide recognition technology
    Hansen, Simon
    Tremmel, Dirk
    Madhurantakam, Chaithanya
    Reichen, Christian
    Mittl, Peer
    Plueckthun, Andreas
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
  • [36] Designed Ankyrin Repeat Proteins: A New Class of Viral Entry Inhibitors
    Walser, Marcel
    Mayor, Jennifer
    Rothenberger, Sylvia
    VIRUSES-BASEL, 2022, 14 (10):
  • [37] Molecular dynamics study of the stabilities of consensus designed ankyrin repeat proteins
    Yu, Haibo
    Kohl, Andreas
    Binz, H. Kaspar
    Plueckthun, Andreas
    Gruetter, Markus G.
    van Gunsteren, Wilfred F.
    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2006, 65 (02) : 285 - 295
  • [38] Crystal structure of a designed tetratricopeptide repeat module in complex with its peptide ligand
    Cortajarena, Aitziber L.
    Wang, Jimin
    Regan, Lynne
    FEBS JOURNAL, 2010, 277 (04) : 1058 - 1066
  • [39] Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects
    Reichen, Christian
    Madhurantakam, Chaithanya
    Hansen, Simon
    Gruetter, Markus G.
    Plueckthun, Andreas
    Mittl, Peer R. E.
    ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2016, 72 : 168 - 175
  • [40] Chloroplast RNA-binding and pentatricopeptide repeat proteins
    Nakamura, T
    Schuster, G
    Sugiura, M
    Sugita, M
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2004, 32 : 571 - 574
12345