Ligand binding by repeat proteins: natural and designed

被引：97
|
作者：
Grove, Tijana Z. [1 ]
Cortajarena, Aitziber L. [1 ]
Regan, Lynne [1 ,2 ]
机构：
[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA
[2] Yale Univ, Dept Chem, New Haven, CT 06520 USA
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 2008年 / 18卷 / 04期
关键词：
D O I：
10.1016/j.sbi.2008.05.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Repeat proteins contain tandem arrays of small structural motifs. As a consequence of this architecture, they adopt non-globular, extended structures that present large, highly specific surfaces for ligand binding. Here we discuss recent advances toward understanding the functional role of this unique modular architecture. We showcase specific examples of natural repeat proteins interacting with diverse ligands and also present examples of designed repeat protein-ligand interactions.
引用
收藏
页码：507 / 515
页数：9
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