Cytotoxic activities of water-soluble chitosan derivatives with different degree of deacetylation

被引：47
|
作者：
Je, JY [1 ]
Cho, YS [1 ]
Kim, SK [1 ]
机构：
[1] Pukyong Natl Univ, Dept Chem, Pusan 608737, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 08期
关键词：
water-soluble; chitosan derivatives; cytotoxic activity;
D O I：
10.1016/j.bmcl.2006.01.060
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Chitosans with different degree of deacetylation (DD) (90% and 50% deacetylated chitosan) were prepared by N-deacetylation followed by grafted onto chitosan to form water-soluble aminoethyl-chitosan (AE-chitosan), and dimetylaminoethyl-chitosan (DMAE-chitosan), diethylaminoethyl-chitosan (DEAE-chitosan). In the present study, cytotoxic activities of the chitosan derivatives were evaluated using three tumor cell lines and two normal cell lines, and structure-activity relationship was suggested. The cytotoxic activity was dependent on their DD and substituted group. (C) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2122 / 2126
页数：5
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