Cytotoxic activities of water-soluble chitosan derivatives with different degree of deacetylation

被引：47
|
作者：
Je, JY [1 ]
Cho, YS [1 ]
Kim, SK [1 ]
机构：
[1] Pukyong Natl Univ, Dept Chem, Pusan 608737, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 08期
关键词：
water-soluble; chitosan derivatives; cytotoxic activity;
D O I：
10.1016/j.bmcl.2006.01.060
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Chitosans with different degree of deacetylation (DD) (90% and 50% deacetylated chitosan) were prepared by N-deacetylation followed by grafted onto chitosan to form water-soluble aminoethyl-chitosan (AE-chitosan), and dimetylaminoethyl-chitosan (DMAE-chitosan), diethylaminoethyl-chitosan (DEAE-chitosan). In the present study, cytotoxic activities of the chitosan derivatives were evaluated using three tumor cell lines and two normal cell lines, and structure-activity relationship was suggested. The cytotoxic activity was dependent on their DD and substituted group. (C) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2122 / 2126
页数：5
相关论文
共 50 条
  • [31] Synthesis of water-soluble chitosan derivatives and their use for the stabilization of liposomal suspensions
    V. S. Ponomarev
    K. V. Kozhikhova
    I. D. Shulepov
    M. I. Tokareva
    M. N. Ivantsova
    M. A. Mironov
    Russian Chemical Bulletin, 2014, 63 : 1619 - 1623
  • [32] Novel water-soluble quaternary piperazine derivatives of chitosan:: Synthesis and characterization
    Holappa, J
    Nevalainen, T
    Safin, R
    Soininen, P
    Asplund, T
    Luttikhedde, T
    Másson, M
    Järvinen, T
    MACROMOLECULAR BIOSCIENCE, 2006, 6 (02) : 139 - 144
  • [33] Protonation constants of chitosan with different molecular weight and degree of deacetylation
    Wang, Qi Zhao
    Chen, Xi Guang
    Liu, Nan
    Wang, Shi Xi
    Liu, Cheng Sheng
    Meng, Xiang Hong
    Liu, Chen Guang
    CARBOHYDRATE POLYMERS, 2006, 65 (02) : 194 - 201
  • [34] Chemical modification of chitosan. 14: Synthesis of water-soluble chitosan derivatives by simple acetylation
    Sashiwa, H
    Kawasaki, N
    Nakayama, A
    Muraki, E
    Yamamoto, N
    Aiba, S
    BIOMACROMOLECULES, 2002, 3 (05) : 1126 - 1128
  • [35] Water-Soluble Polyplexes of Modified Chitosan
    Kostina, N. Yu.
    Gorshkova, M. Yu.
    Izumrudov, V. A.
    POLYMER SCIENCE SERIES A, 2011, 53 (10) : 947 - 954
  • [36] Water-soluble chitosan graft polymers
    The Petroleum and Petrochemical College, Chulalongkorn University, Phya Thai, Bangkok 10330, Thailand
    Ind Bioprocess, 2006, 4 (08):
  • [37] Water-soluble amino functionalized chitosan: Preparation, characterization, antioxidant and antibacterial activities
    Yuan, Yuting
    Tan, Wenqiang
    Zhang, Jingjing
    Li, Qing
    Guo, Zhanyong
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 217 : 969 - 978
  • [38] WATER-SOLUBLE DERIVATIVES OF REBECCAMYCIN
    KANEKO, T
    WONG, H
    UTZIG, J
    SCHURIG, J
    DOYLE, TW
    JOURNAL OF ANTIBIOTICS, 1990, 43 (01): : 125 - 127
  • [39] Water-soluble cellulose derivatives
    Hayakawa, Kazuhisa, 1600, Society of Fiber Science and Technology (70):
  • [40] Water-soluble polyplexes of modified chitosan
    N. Yu. Kostina
    M. Yu. Gorshkova
    V. A. Izumrudov
    Polymer Science Series A, 2011, 53 : 947 - 954
12345