Comparison of myelin water fraction values in periventricular white matter lesions between multiple sclerosis and neuromyelitis optica spectrum disorder

被引：24

作者：

Jeong, In Hye ^{[1
]}

Choi, Joon Yul ^{[2
]}

Kim, Su-Hyun ^{[1
]}

Hyun, Jae-Won ^{[1
]}

Joung, AeRan ^{[1
]}

Lee, Jongho ^{[2
]}

Kim, Ho Jin ^{[1
]}

机构：

[1] Natl Canc Ctr, Res Inst & Hosp, Dept Neurol, 323 Ilsan St, Goyang Si 410769, Gyeonggi Do, South Korea

[2] Seoul Natl Univ, Dept Elect & Comp Engn, Bldg 301,Room 1008,1 Gwanak Ro, Seoul 08826, South Korea

来源：

MULTIPLE SCLEROSIS JOURNAL | 2016年 / 22卷 / 12期

关键词：

Myelin water imaging; multiple sclerosis; neuromyelitis optica spectrum disorder; demyelination; BRAIN-LESIONS; DEMYELINATION; PATHOLOGY;

D O I：

10.1177/1352458516636247

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory autoimmune diseases of the central nervous system. We hypothesized that the degree of demyelination within lesions in MS and NMOSD would differ as the pathophysiology of the two diseases do. We used myelin water imaging to compare the myelin water fraction (MWF) in 106 periventricular white matter (PVWM) lesions in 27 MS patients and 51 PVWM lesions in 20 NMOSD patients. The MWF was significantly reduced in the MS compared with the NMOSD lesions, suggesting that myelin loss was more severe in MS than in NMOSD.

引用

页码：1616 / 1620

页数：5

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