Synthesis of oligodeoxynucleotides containing 4′-C-aminoalkylthymidines and their thermal stability and nuclease-resistance properties

被引：1
|
作者：
Ueno, Y [1 ]
Kanazaki, M [1 ]
Shuto, S [1 ]
Matsuda, A [1 ]
机构：
[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan
来源：
NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 6-7期
关键词：
D O I：
10.1080/07328319908044731
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To find the nuclease-resistant oligodeoxynucleotides (ODNs) with natural phosphodiester linkages, we designed and synthesized ODNs containing 4'-C-aminoalkylthymidines (1-4). We found that the ODNs containing 1, 2, 3 or 4 were more resistant to nucleolytic hydrolysis by both snake venom phosphodiesterase (a 3'-exonuclease) and DNase I (an endonuclease) than unmodified ODNs.
引用
收藏
页码：1401 / 1402
页数：2
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