Traveling Wave Ion Mobility Mass Spectrometry Study of Low Generation Polyamidoamine Dendrimers

被引：15
|
作者：
Maire, Florian [1 ,2 ,3 ]
Coadou, Gael [1 ,2 ,3 ]
Cravello, Laetitia [4 ]
Lange, Catherine M. [1 ,2 ,3 ]
机构：
[1] Univ Rouen, IRCOF, Mont St Aignan, France
[2] INSA Rouen, St Etienne, France
[3] CNRS, UMR 6014, COBRA, Mont St Aignan, France
[4] Waters Corp, Manchester, Lancs, England
来源：
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2013年 / 24卷 / 02期
关键词：
Polyamidoamine dendrimers; Defective structure; Ion mobility mass spectrometry; Traveling wave; Collision cross-section; Electrospray; POLY(PROPYLENE IMINE) DENDRIMERS; POLY(AMINO)ESTER DENDRIMERS; POLY(AMIDOAMINE) DENDRIMERS; STRUCTURAL-CHARACTERIZATION; MALDI; FRAGMENTATION; DEVIATIONS; SPECTRA; MS;
D O I：
10.1007/s13361-012-0527-3
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We reported the use of ion mobility (IM) combined with mass spectrometry (MS) as an analytical tool to investigate low generation polyamidoanine (PAMAM) dendrimers. This analytical approach has been employed to separate ions of defective structures with different charge state but exactly the same m/z value. Tandem mass spectrometry (MS/MS) after IM separation allowed a comprehensive structural characterization of defective dendrimers. In addition, IM was used to evaluate the collision cross-sections of ions of perfect dendrimers. They showed a good correlation with calculated collision cross-sections obtained by the trajectory method (TM) and were also consistent with dimensions reported by other established analytical methods.
引用
收藏
页码：238 / 248
页数：11
相关论文
共 50 条
  • [41] Separation of isomeric disaccharides by traveling wave ion mobility mass spectrometry using CO2 as drift gas
    Fasciotti, Maira
    Sanvido, Gustavo B.
    Santos, Vanessa G.
    Lalli, Priscila M.
    McCullagh, Michael
    de Sa, Gilberto F.
    Daroda, Romeu J.
    Peter, Martin G.
    Eberlin, Marcos N.
    JOURNAL OF MASS SPECTROMETRY, 2012, 47 (12): : 1643 - 1647
  • [42] Corrole isomers: intrinsic gas-phase shapes via traveling wave ion mobility mass spectrometry and dissociation chemistries via tandem mass spectrometry
    Fasciotti, Maira
    Gomes, Alexandre F.
    Gozzo, Fabio C.
    Iglesias, Bernardo A.
    de Sa, Gilberto F.
    Daroda, Romeu J.
    Toganoh, Motoki
    Furuta, Hiroyuki
    Araki, Koiti
    Eberlin, Marcos N.
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 10 (42) : 8396 - 8402
  • [43] Ion Mobility Mass Spectrometry
    Barran, Perdita
    Ruotolo, Brandon
    ANALYST, 2015, 14 (20) : 6772 - 6774
  • [44] Peak width-mass correlation in CID MS/MS of isomeric oligosaccharides using traveling-wave ion mobility mass spectrometry
    Yamagaki, Tohru
    Sato, Akihiro
    JOURNAL OF MASS SPECTROMETRY, 2009, 44 (10): : 1509 - 1517
  • [45] Identification and separation of saxitoxins using hydrophilic interaction liquid chromatography coupled to traveling wave ion mobility-mass spectrometry
    Poyer, Salome
    Loutelier-Bourhis, Corinne
    Coadou, Gael
    Mondeguer, Florence
    Enche, Julien
    Bossee, Anne
    Hess, Philipp
    Afonso, Carlos
    JOURNAL OF MASS SPECTROMETRY, 2015, 50 (01): : 175 - 181
  • [46] Petroleomics by ultra-high resolution mass spectrometry in a "zig-zag" multi-reflecting TOF and via traveling wave ion mobility mass spectrometry
    Eberlin, Marcos N.
    Klitzke, Clecio F.
    Fasciotti, Maira
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
  • [47] Gas phase conformations of monocyte chemoattractant protein-1: An investigation using traveling wave ion mobility mass spectrometry
    Xun, Zhiyin
    Leary, Julie A.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 239
  • [48] Dividing To Unveil Protein Microheterogeneities: Traveling Wave Ion Mobility Study
    Halgand, F.
    Habchi, Johnny
    Cravello, Laetitia
    Martinho, Marlene
    Guigliarelli, Bruno
    Longhi, Sonia
    ANALYTICAL CHEMISTRY, 2011, 83 (19) : 7306 - 7315
  • [49] Developments in ion mobility spectrometry–mass spectrometry
    D. Collins
    M. Lee
    Analytical and Bioanalytical Chemistry, 2002, 372 : 66 - 73
  • [50] Low-Generation Polyamidoamine Dendrimers as Drug Carriers for Platinum(IV) Complexes
    Sommerfeld, Nadine S.
    Hejl, Michaela
    Klose, Matthias H. M.
    Schreiber-Brynzak, Ekaterina
    Bileck, Andrea
    Meier, Samuel M.
    Gerner, Christopher
    Jakupec, Michael A.
    Galanski, Markus
    Keppler, Bernhard K.
    EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2017, (12) : 1713 - 1720
12345