Traveling Wave Ion Mobility Mass Spectrometry Study of Low Generation Polyamidoamine Dendrimers

被引：15
|
作者：
Maire, Florian [1 ,2 ,3 ]
Coadou, Gael [1 ,2 ,3 ]
Cravello, Laetitia [4 ]
Lange, Catherine M. [1 ,2 ,3 ]
机构：
[1] Univ Rouen, IRCOF, Mont St Aignan, France
[2] INSA Rouen, St Etienne, France
[3] CNRS, UMR 6014, COBRA, Mont St Aignan, France
[4] Waters Corp, Manchester, Lancs, England
来源：
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2013年 / 24卷 / 02期
关键词：
Polyamidoamine dendrimers; Defective structure; Ion mobility mass spectrometry; Traveling wave; Collision cross-section; Electrospray; POLY(PROPYLENE IMINE) DENDRIMERS; POLY(AMINO)ESTER DENDRIMERS; POLY(AMIDOAMINE) DENDRIMERS; STRUCTURAL-CHARACTERIZATION; MALDI; FRAGMENTATION; DEVIATIONS; SPECTRA; MS;
D O I：
10.1007/s13361-012-0527-3
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We reported the use of ion mobility (IM) combined with mass spectrometry (MS) as an analytical tool to investigate low generation polyamidoanine (PAMAM) dendrimers. This analytical approach has been employed to separate ions of defective structures with different charge state but exactly the same m/z value. Tandem mass spectrometry (MS/MS) after IM separation allowed a comprehensive structural characterization of defective dendrimers. In addition, IM was used to evaluate the collision cross-sections of ions of perfect dendrimers. They showed a good correlation with calculated collision cross-sections obtained by the trajectory method (TM) and were also consistent with dimensions reported by other established analytical methods.
引用
收藏
页码：238 / 248
页数：11
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