Method and device for non-invasive blood glucose measurement

被引：0
|
作者：
Amerov, AK [1 ]
Jeon, KJ [1 ]
Kim, YJ [1 ]
Yoon, G [1 ]
机构：
[1] Samsung Adv Inst Technol, Biomed Engn Res Ctr, Suwon 440600, South Korea
来源：
OPTICAL DIAGNOSTICS OF BIOLOGICAL FLUIDS IV, PROCEEDINGS OF | 1999年 / 3599卷
关键词：
glucose; non-invasive; NIR spectroscopy; wavelength selection;
D O I：
10.1117/12.348382
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
The method and device for non-invasive measurement of blood glucose concentration based on the diffuse reflectance from the transcutaneous layers is proposed. Original normalizing ratio algorithm permitting to separate glucose absorption from absorption of other blood components is suggested. It was shown that the influence of water and some other components such as hemoglobin, albumin, globulin's and cholesterol concentration variations to the estimation of the glucose concentration can be compensated using spectral analysis of the reflection on several specially selected wavelengths and proposed algorithm. Device with optical geometry minimizing the effects of changes in the scattering background of biological tissues was developed. NIR spectral range 800 - 1800 nm was used because of its good transparency for biological tissue and presence of glucose absorption band. We used two kinds of light sources, namely LED array and Xe flash lamp. Tissue phantoms (different glucose concentration (0 - 1000 mg/dl) solutions with polystyrene beads or with milk) were used as samples. Scattering and absorption contribution to the dependence of diffuse reflection on glucose concentration was experimentally verified.
引用
收藏
页码：33 / 42
页数：4
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