A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO)

被引：13
|
作者：
Piccinonna, Sara [1 ]
Margiotta, Nicola [1 ]
Denora, Nunzio [2 ]
Iacobazzi, Rosa Maria [2 ]
Pacifico, Concetta [1 ]
Trapani, Giuseppe [2 ]
Natile, Giovanni [1 ]
机构：
[1] Univ Studi Bari Aldo Moro, Dipartimento Chim, I-70125 Bari, Italy
[2] Univ Studi Bari Aldo Moro, Dipartimento Farm Sci Farmaco, I-70125 Bari, Italy
来源：
DALTON TRANSACTIONS | 2013年 / 42卷 / 28期
关键词：
PERIPHERAL BENZODIAZEPINE-RECEPTOR; PLATINUM(II) COMPLEXES; SELECTIVE LIGANDS; BINDING-AFFINITY; IN-VITRO; PROLIFERATION; EXPRESSION; APOPTOSIS; RHENIUM; CANCER;
D O I：
10.1039/c3dt51152a
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A stable Re complex containing an imidazopyridine ligand with a high affinity for TSPO has been synthesized as a model for new Tc-99m or Re-188/186-based radiopharmaceuticals to be used in SPECT diagnosis or in therapy, respectively. The new complex fac-[ReBr(CO)(3)(TZ6)], structurally characterized, showed high affinity (nanomolar concentration) for the target protein.
引用
下载
收藏
页码：10112 / 10115
页数：4
相关论文
共 50 条
  • [41] Regulation of Mitochondrial Signaling and Quality Control by the 18KDA Translocator Protein (TSPO)
    Gatliff, Jemma L.
    East, Daniel
    Turkheimer, Federico
    Campanella, Michelangelo
    BIOPHYSICAL JOURNAL, 2016, 110 (03) : 473A - 473A
  • [42] Translocator protein (TSPO 18 kDa) is expressed by neural stem and neuronal precursor cells
    Varga, Balazs
    Marko, Karoly
    Hadinger, Nora
    Jelitai, Marta
    Demeter, Kornel
    Tihanyi, Karoly
    Vas, Adam
    Madarasz, Emilia
    NEUROSCIENCE LETTERS, 2009, 462 (03) : 257 - 262
  • [43] Recent progress on the development of fluorescent probes targeting the translocator protein 18 kDa (TSPO)
    Wongso, Hendris
    ANALYTICAL BIOCHEMISTRY, 2022, 655
  • [44] The mitochondrial translocator protein (TSPO, 18 kDa): A key multifunctional molecule in liver diseases
    Li, Yuchang
    Chen, Liting
    Papadopoulos, Vassilios
    BIOCHIMIE, 2024, 224 : 91 - 103
  • [45] The Role of 18 kDa Mitochondrial Translocator Protein (TSPO) in Programmed Cell Death, and Effects of Steroids on TSPO Expression
    Veenman, L.
    Gavish, M.
    CURRENT MOLECULAR MEDICINE, 2012, 12 (04) : 398 - 412
  • [46] Crystal Structures of Translocator Protein 18 kDA (TSPO) and Identification of a Cholesterol Binding Enhancement Motif
    Li, Fei
    Liu, Jian
    Hiser, Carrie
    Valls, Lance
    Garavito, Michael
    Ferguson-Miller, Shelagh
    BIOPHYSICAL JOURNAL, 2015, 108 (02) : 308A - 308A
  • [47] In vitro and pilot in vivo imaging of 18 kDa translocator protein (TSPO) in inflammatory vascular disease
    Schollhammer, Romain
    Lepreux, Sebastien
    Barthe, Nicole
    Vimont, Delphine
    Rullier, Anne
    Sibon, Igor
    Berard, Xavier
    Zhang, Andrea
    Kimura, Yasuyuki
    Fujita, Masahiro
    Innis, Robert B.
    Zanotti-Fregonara, Paolo
    Morgat, Clement
    EJNMMI RESEARCH, 2021, 11 (01)
  • [48] Enhancing Neurosteroid Synthesis - Relationship to the Pharmacology of Translocator Protein (18 kDa) (TSPO) Ligands and Benzodiazepines
    Wolf, L.
    Bauer, A.
    Melchner, D.
    Hallof-Buestrich, H.
    Stoertebecker, P.
    Haen, E.
    Kreutz, M.
    Sarubin, N.
    Milenkovic, V. M.
    Wetzel, C. H.
    Rupprecht, R.
    Nothdurfter, C.
    PHARMACOPSYCHIATRY, 2015, 48 (02) : 72 - 77
  • [49] Sex Differences in Translocator Protein 18 kDa (TSPO) in the Heart: Implications for Imaging Myocardial Inflammation
    DeLisa Fairweather
    Michael J. Coronado
    Amanda E. Garton
    Jennifer L. Dziedzic
    Adriana Bucek
    Leslie T. Cooper
    Jessica E. Brandt
    Fatima S. Alikhan
    Haofan Wang
    Christopher J. Endres
    Judy Choi
    Martin G. Pomper
    Tomás R. Guilarte
    Journal of Cardiovascular Translational Research, 2014, 7 : 192 - 202
  • [50] T cell-dependent regulatory roles of 18-kDa Translocator protein (TSPO)
    Sendai, Yuka
    Takeda, Kazuyoshi
    Ichinohe, Tatsuya
    Koshika, Kyotaro
    Okumura, Ko
    Azuma, Toshifumi
    Ohno, Tatsukuni
    JOURNAL OF IMMUNOLOGY, 2023, 210 (01):
12345