A model radiopharmaceutical agent targeted to translocator protein 18 kDa (TSPO)

被引：13
|
作者：
Piccinonna, Sara [1 ]
Margiotta, Nicola [1 ]
Denora, Nunzio [2 ]
Iacobazzi, Rosa Maria [2 ]
Pacifico, Concetta [1 ]
Trapani, Giuseppe [2 ]
Natile, Giovanni [1 ]
机构：
[1] Univ Studi Bari Aldo Moro, Dipartimento Chim, I-70125 Bari, Italy
[2] Univ Studi Bari Aldo Moro, Dipartimento Farm Sci Farmaco, I-70125 Bari, Italy
来源：
DALTON TRANSACTIONS | 2013年 / 42卷 / 28期
关键词：
PERIPHERAL BENZODIAZEPINE-RECEPTOR; PLATINUM(II) COMPLEXES; SELECTIVE LIGANDS; BINDING-AFFINITY; IN-VITRO; PROLIFERATION; EXPRESSION; APOPTOSIS; RHENIUM; CANCER;
D O I：
10.1039/c3dt51152a
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A stable Re complex containing an imidazopyridine ligand with a high affinity for TSPO has been synthesized as a model for new Tc-99m or Re-188/186-based radiopharmaceuticals to be used in SPECT diagnosis or in therapy, respectively. The new complex fac-[ReBr(CO)(3)(TZ6)], structurally characterized, showed high affinity (nanomolar concentration) for the target protein.
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页码：10112 / 10115
页数：4
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