Regulated intratumoral expression of IL-12 in combination with cytotoxic agents as a strategy for the treatment of metastatic breast cancer

被引:0
|
作者
Nemunaitis, J.
McArthur, H.
Hudis, C.
Reed, T.
Broder, S.
Lebel, F.
Barrett, J.
Lewis, J.
Norton, L.
机构
关键词
D O I
10.1158/0008-5472.SABCS13-P5-02-01
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
P5-02-01
引用
收藏
页数:2
相关论文
共 50 条
  • [31] Regulated Expression of IL-12 as Gene Therapy Concomitant with Blockade of PD-1 for Treatment of Glioma
    Barrett, John A.
    Cai, Hongliang
    Miao, John
    Murray, Margaret
    Gonzales, Paul
    Krishnan, Suma
    Lebel, Francois
    Cooper, Laurence J. N.
    MOLECULAR THERAPY, 2016, 24 : S203 - S203
  • [32] Combination of standard cytotoxic agents with polyamine analogues in the treatment of breast cancer cell lines
    Hahm, HA
    Dunn, VR
    Butash, KA
    Deveraux, WL
    Woster, PM
    Casero, RA
    Davidson, NE
    CLINICAL CANCER RESEARCH, 2001, 7 (02) : 391 - 399
  • [33] Safety and efficacy of Tet-regulated IL-12 expression in cancer-specific T cells
    Alsaieedi, Ahdab
    Holler, Angelika
    Velica, Pedro
    Bendle, Gavin
    Stauss, Hans J.
    ONCOIMMUNOLOGY, 2019, 8 (03):
  • [34] Combination of local, nonviral IL12 gene therapy and systemic paclitaxel treatment in a metastatic breast cancer model
    Janát-Amsbury, MM
    Yockman, JW
    Lee, M
    Kern, S
    Furgeson, DY
    Bikram, M
    Kim, SW
    MOLECULAR THERAPY, 2004, 9 (06) : 829 - 836
  • [35] Preliminary experience with rHu IL-12 in the treatment of metastatic melanoma.
    DelVecchio, M
    Mortarini, R
    Rimassa, L
    Fowst, C
    Anichini, A
    Parmiani, G
    Cascinelli, N
    Bajetta, E
    JOURNAL OF CLINICAL ONCOLOGY, 1996, 14 (05) : 2011 - 2011
  • [36] Determination of paraneoplastic autoimmune responses by tumor cell biology and intratumoral IFN-alpha/IL-12 in breast cancer patients
    Domschke, Christoph
    Schuetz, Florian
    Ge, Yingzi
    Rom, Joachim
    Zorn, Markus
    Sinn, Hans-Peter
    Marme, Frederik
    Schott, Sarah
    Heil, Joerg
    Scharf, Alexander
    Sohn, Christof
    Schneeweiss, Andreas
    Beckhove, Philipp
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2011, 60 (03) : 401 - 411
  • [37] Determination of paraneoplastic autoimmune responses by tumor cell biology and intratumoral IFN-alpha/IL-12 in breast cancer patients
    Christoph Domschke
    Florian Schuetz
    Yingzi Ge
    Joachim Rom
    Markus Zorn
    Hans-Peter Sinn
    Frederik Marmé
    Sarah Schott
    Joerg Heil
    Alexander Scharf
    Christof Sohn
    Andreas Schneeweiss
    Philipp Beckhove
    Cancer Immunology, Immunotherapy, 2011, 60 : 401 - 411
  • [38] Interleukin (IL)-12 and IL-12 gene transfer up-regulate Fas expression in human osteosarcoma and breast cancer cells
    Lafleur, EA
    Jia, SF
    Worth, LL
    Zhou, ZC
    Owen-Schaub, LB
    Kleinerman, ES
    CANCER RESEARCH, 2001, 61 (10) : 4066 - 4071
  • [39] Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4
    Lim, YC
    Henault, L
    Wagers, AJ
    Kansas, GS
    Luscinskas, FW
    Lichtman, AH
    JOURNAL OF IMMUNOLOGY, 1999, 162 (06): : 3193 - 3201
  • [40] IL-12 regulates VEGF and MMPs in a murine breast cancer model
    Dias, S
    Boyd, R
    Balkwill, F
    INTERNATIONAL JOURNAL OF CANCER, 1998, 78 (03) : 361 - 365