Ablation of B7-H3 but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer

被引：42

作者：

Kreymborg, Katharina ^{[1
,2
]}

Haak, Stefan ^{[3
,4
,5
]}

Murali, Rajmohan ^{[6
,7
]}

Wei, Joyce ^{[8
]}

Waitz, Rebecca ^{[1
,2
]}

Gasteiger, Georg ^{[1
,2
]}

Savage, Peter A. ^{[9
]}

van den Brink, Marcel R. M. ^{[10
]}

Allison, James P. ^{[1
,2
,8
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Program Immunol, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Ludwig Ctr Canc Immunotherapy, New York, NY 10021 USA

[3] Columbia Univ, Med Ctr, New York, NY USA

[4] Tech Univ Munich, Ctr Allergy & Environm ZAUM, D-80290 Munich, Germany

[5] Helmholtz Ctr Munich, Munich, Germany

[6] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA

[7] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA

[8] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

[9] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

[10] Mem Sloan Kettering Canc Ctr, Dept Immunol & Med, New York, NY 10021 USA

来源：

CANCER IMMUNOLOGY RESEARCH | 2015年 / 3卷 / 08期

基金：

瑞士国家科学基金会;

关键词：

REGULATORY T-CELLS; IFN-GAMMA; B7; FAMILY; EXPRESSION; IMMUNOTHERAPY; MEMBER; MOUSE;

D O I：

10.1158/2326-6066.CIR-15-0100

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The costimulatory molecules B7-H3 and B7-H4 are over-expressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional implication in tumor-host interaction hampers their evaluation as a target for cancer therapy. By means of a highly physiologic, spontaneous tumor model in mice, we establish a causal link between B7-H3 and host tumor control and found B7-H4 to be redundant.

引用

页码：849 / 854

页数：6

共 50 条

[31] B7-H3 Expression in NSCLC and Its Association with B7-H4, PD-L1 and Tumor-Infiltrating Lymphocytes
Altan, Mehmet
Pelekanou, Vasiliki
Schalper, Kurt A.
Toki, Maria
Gaule, Patricia
Syrigos, Konstantinos
Herbst, Roy S.
Rimm, David L.
CLINICAL CANCER RESEARCH, 2017, 23 (17) : 5202 - 5209
[32] B7-H3: a robust target for immunotherapy in prostate cancer
Pulido, Rafael
Lopez, Jose I.
Nunes-Xavier, Caroline E.
TRENDS IN CANCER, 2024, 10 (07) : 584 - 587
[33] B7-H3 immune checkpoint molecule in prostate cancer
Ntala, C.
Salmond, J.
Blomme, A.
Ahmad, I.
Leung, H.
VIRCHOWS ARCHIV, 2022, 481 (SUPPL 1) : S168 - S169
[34] B7-H3 as a therapeutic target in prostate cancer.
Guo, Christina
Figueiredo, Ines
Gurel, Bora
Crespo, Matues
Rekowski, Jan
Carreira, Suzanne
Neeb, Antje
Sharp, Adam
de la Maza, Maria D. Fenor
Rescigno, Pasquale
Chandran, Khobe
Ferreira, Ana
Riisnaes, Ruth
Miranda, Susana
Pereira, Rita
Gil, Veronica
Seed, George
Bertan, Claudia
Baker, Chloe
Yuan, Wei
de Bono, Johann S.
CANCER RESEARCH, 2021, 81 (13)
[35] High B7-H3 expression is linked to increased risk of prostate cancer progression
Bonk, Sarah
Tasdelen, Pinar
Kluth, Martina
Hube-Magg, Claudia
Makrypidi-Fraune, Georgia
Moeller, Katharina
Hoeflmayer, Doris
Rico, Sebastian Dwertmann
Buescheck, Franziska
Minner, Sarah
Heinzer, Hans
Graefen, Markus
Hinsch, Andrea
Luebke, Andreas M.
Dum, David
Uhlig, Ria
Schlomm, Thorsten
Sauter, Guido
Simon, Ronald
Weideman, Soeren A.
PATHOLOGY INTERNATIONAL, 2020, 70 (10) : 733 - 742
[36] B7-H3 is related to tumor progression in ovarian cancer
Zhang, Jingjing
Liu, Lu
Han, Sai
Li, Yi
Qian, Qiuhong
Zhang, Qianqian
Zhang, Hui
Yang, Ziyan
Zhang, Youzhong
ONCOLOGY REPORTS, 2017, 38 (04) : 2426 - 2434
[37] Expressions of B7-H4 and B7-H3 Proteins and Effect of Sorafenib on their Expressions in Different Human Hepatoma Cell Lines
Shen, Ya-Ping
Zhang, Shuai
Wang, Li-Zhou
Yang, Xi-Yuan
Liu, Wei-Xin
Long, Ji-Fu
Zhou, Shi
Li, Kun
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2015, 14 (10) : 1797 - 1802
[38] RETRACTION: The Coexpression and Clinical Significance of Costimulatory Molecules B7-H1, B7-H3, and B7-H4 in Human Pancreatic Cancer (Retraction of Vol 7, Pg 1465, 2014)
Chen, Y.
Sun, J.
Zhao, H.
ONCOTARGETS AND THERAPY, 2022, 15 : 699 - 699
[39] B7-H3 Over Expression in Prostate Cancer Promotes Tumor Cell Progression
Yuan, Hexing
Wei, Xuedong
Zhang, Guangbo
Li, Chen
Zhang, Xueguang
Hou, Jianquan
JOURNAL OF UROLOGY, 2011, 186 (03): : 1093 - 1099
[40] B7-H4 is highly expressed in ductal and lobular breast cancer
Tringler, B
Zhuo, SQ
Pilkington, G
Torkko, KC
Singh, M
Lucia, MS
Heinz, DE
Papkoff, J
Shroyer, KR
CLINICAL CANCER RESEARCH, 2005, 11 (05) : 1842 - 1848

← 1 2 3 4 5 →