Ablation of B7-H3 but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer

被引：42
|
作者：
Kreymborg, Katharina [1 ,2 ]
Haak, Stefan [3 ,4 ,5 ]
Murali, Rajmohan [6 ,7 ]
Wei, Joyce [8 ]
Waitz, Rebecca [1 ,2 ]
Gasteiger, Georg [1 ,2 ]
Savage, Peter A. [9 ]
van den Brink, Marcel R. M. [10 ]
Allison, James P. [1 ,2 ,8 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Program Immunol, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Ludwig Ctr Canc Immunotherapy, New York, NY 10021 USA
[3] Columbia Univ, Med Ctr, New York, NY USA
[4] Tech Univ Munich, Ctr Allergy & Environm ZAUM, D-80290 Munich, Germany
[5] Helmholtz Ctr Munich, Munich, Germany
[6] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA
[7] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10021 USA
[8] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA
[9] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
[10] Mem Sloan Kettering Canc Ctr, Dept Immunol & Med, New York, NY 10021 USA
来源：
CANCER IMMUNOLOGY RESEARCH | 2015年 / 3卷 / 08期
基金：
瑞士国家科学基金会;
关键词：
REGULATORY T-CELLS; IFN-GAMMA; B7; FAMILY; EXPRESSION; IMMUNOTHERAPY; MEMBER; MOUSE;
D O I：
10.1158/2326-6066.CIR-15-0100
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The costimulatory molecules B7-H3 and B7-H4 are over-expressed in a variety of human tumors and have been hypothesized as possible biomarkers and immunotherapeutic targets. Despite this potential, the predominating uncertainty about their functional implication in tumor-host interaction hampers their evaluation as a target for cancer therapy. By means of a highly physiologic, spontaneous tumor model in mice, we establish a causal link between B7-H3 and host tumor control and found B7-H4 to be redundant.
引用
收藏
页码：849 / 854
页数：6
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