3-Hydroxy-3-Methylglutaryl Flavonol Glycosides from Oxytropis falcata

被引：32
|
作者：
Wang, Shan-Shan [1 ,2 ]
Zhang, Xiao-Jing [1 ,2 ]
Que, Sheng [3 ]
Tu, Guang-Zhong [4 ]
Wan, Dan [1 ,2 ]
Cheng, Wei [1 ,2 ]
Liang, Hong [1 ,2 ]
Ye, Jia [1 ,2 ]
Zhang, Qing-Ying [1 ,2 ]
机构：
[1] Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
[2] Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China
[3] Qinghai Teachers Univ, Minor Teachers Coll, Dept Chem, Xining 810008, Peoples R China
[4] Beijing Inst Microchem, Beijing 100091, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 07期
基金：
中国国家自然科学基金;
关键词：
ACYL GROUP; CONSTITUENTS; CHIRALITY; SAPONINS; LEAVES; ROOTS;
D O I：
10.1021/np300292f
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Five new 3-hydroxy-3-methylglutaryl (HMG) flavonol 3-O-glycosides, named oxytroflavosides A-E (1-5), and two new rhamnocitrin 3-O-glycosides, oxytroflavosides F and G (6 and 7) were isolated from the n-BuOH-soluble fraction of an EtOH extract of Oxytropis falcata together with seven known kaempferol glycosides (8-14), of which six were isolated from the genus Oxytropis for the first time. The structures of these compounds were elucidated by spectroscopic techniques and chemical methods. The absolute configuration of HMG in compounds 1-5 was determined to be S through spectroscopic analysis of the mevalonamide obtained by amidation and reduction of the HMG moiety. Compounds 1-10 were evaluated for anti-inflammatory activities using lipopolysaccharide-induced RAW 264.7 cells, but none of them showed inhibitory effects on NO production.
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页码：1359 / 1364
页数：6
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