Isoflavones inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro

被引：42
|
作者：
Sung, JH
Lee, SJ
Park, KH
Moon, TW [1 ]
机构：
[1] Seoul Natl Univ, Dept Food Sci & Technol, Sch Agr Biotechnol, Seoul 151742, South Korea
[2] Seoul Natl Univ, Ctr Agr Biomat, Seoul 151742, South Korea
[3] Palo Alto Med Res Fdn, Stanford Sch Med, Palo Alto, CA 94301 USA
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2004年 / 68卷 / 02期
关键词：
isoflavone; HMG-CoA reductase; genistein; cholesterol; soybean;
D O I：
10.1271/bbb.68.428
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Isoflavones identified as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in soybean paste were assayed using the catalytic portion of Syrian hamster HMG-CoA reductase, and the kinetic values were measured using HMG-CoA and NADPH. The inhibition of HMG-CoA reductase by these inhibitors was competitive with HMG-CoA and noncompetitive with NADPH. K-i values for genistein, daidzein, and glycitein were 27.7, 49.5, and 94.7 mum, respectively.
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页码：428 / 432
页数：5
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