Activity of the Inflammatory Process in Different Types of Unstable Atherosclerotic Plaques

被引：21

作者：

Ragino, Yu I. ^{[1
]}

Chernyavski, A. M. ^{[2
]}

Polonskaya, Ya V. ^{[1
]}

Volkov, A. M. ^{[2
]}

Kashtanova, E. V. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Therapy, Siberian Div, Novosibirsk, Russia

[2] Fed Agcy High Technol Med Care, EN Meshalkin Res Inst Circulatory Pathol, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2012年 / 153卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

atherosclerotic plaques of coronary arteries; lipid; inflammatory erosive; and degenerative necrotic types of unstable plaques; inflammatory cytokines; chemoattractants; VULNERABLE PLAQUE; PART I; BIOMARKERS; RISK;

D O I：

10.1007/s10517-012-1672-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Inflammatory biomarkers and chemoattractants characteristic and important for different types (lipid; inflammatory erosive; degenerative necrotic) of unstable plaques in coronary arteries were identified and studied in male patients with coronary atherosclerosis without acute coronary syndrome we studied. Among the three types of unstable plaques, elevated concentrations of IL-1 beta, IL-6, IL-8, IL-18 and monocyte chemotactic protein-1 were characteristic of not only inflammatory erosive type, but also lipid type compared with degenerative necrotic type. Thus, intensification of the inflammatory process plays an important role in the development of not only inflammatory and destructive, but also of lipid type of unstable atherosclerotic plaques.

引用

页码：186 / 189

页数：4

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