Activity of the Inflammatory Process in Different Types of Unstable Atherosclerotic Plaques

被引：21

作者：

Ragino, Yu I. ^{[1
]}

Chernyavski, A. M. ^{[2
]}

Polonskaya, Ya V. ^{[1
]}

Volkov, A. M. ^{[2
]}

Kashtanova, E. V. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Therapy, Siberian Div, Novosibirsk, Russia

[2] Fed Agcy High Technol Med Care, EN Meshalkin Res Inst Circulatory Pathol, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2012年 / 153卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

atherosclerotic plaques of coronary arteries; lipid; inflammatory erosive; and degenerative necrotic types of unstable plaques; inflammatory cytokines; chemoattractants; VULNERABLE PLAQUE; PART I; BIOMARKERS; RISK;

D O I：

10.1007/s10517-012-1672-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Inflammatory biomarkers and chemoattractants characteristic and important for different types (lipid; inflammatory erosive; degenerative necrotic) of unstable plaques in coronary arteries were identified and studied in male patients with coronary atherosclerosis without acute coronary syndrome we studied. Among the three types of unstable plaques, elevated concentrations of IL-1 beta, IL-6, IL-8, IL-18 and monocyte chemotactic protein-1 were characteristic of not only inflammatory erosive type, but also lipid type compared with degenerative necrotic type. Thus, intensification of the inflammatory process plays an important role in the development of not only inflammatory and destructive, but also of lipid type of unstable atherosclerotic plaques.

引用

页码：186 / 189

页数：4

共 50 条

[31] Activity of inflammatory-destructive changes during of unstable atherosclerotic plaque formation
Ragino, Y. I.
Chernjavski, A. M.
Polonskajal, Y. V.
Volkov, A. M.
Semaeva, E. V.
Voevoda, M. I.
ATHEROSCLEROSIS SUPPLEMENTS, 2007, 8 (01) : 92 - 92
[32] PROCOAGULANT ACTIVITY OF CORONARY ATHEROSCLEROTIC PLAQUES
LUCORE, CL
WINTERS, KJ
EISENBERG, PR
CIRCULATION, 1992, 86 (04) : 20 - 20
[33] Collagenase activity in unstable carotid plaques
Molloy, KJ
Loftus, IM
Evans, J
Bell, PRF
Naylor, AR
Thompson, MM
BRITISH JOURNAL OF SURGERY, 2003, 90 (05) : 633 - 634
[34] Sirtuin 6 Expression and Inflammatory Activity in Diabetic Atherosclerotic Plaques: Effects of Incretin Treatment
Balestrieri, Maria Luisa
Rizzo, Maria Rosaria
Barbieri, Michelangela
Paolisso, Pasquale
D'Onofrio, Nunzia
Giovane, Alfonso
Siniscalchi, Mario
Minicucci, Fabio
Sardu, Celestino
D'Andrea, Davide
Mauro, Ciro
Ferraraccio, Franca
Servillo, Luigi
Chirico, Fabio
Caiazzo, Pasquale
Paolisso, Giuseppe
Marfella, Raffaele
DIABETES, 2015, 64 (04) : 1395 - 1406
[35] Expression and activity of the cysteine protease, legumain, is up-regulated in unstable REGIONS OF human atherosclerotic plaques
Mattock, K. L.
Burnand, K.
Gough, P.
Patel, L.
Watts, C.
Taylor, P.
Smith, A.
ATHEROSCLEROSIS, 2007, 193 (02) : S4 - S4
[36] miRNA-16/21 as a biomarker for coronary atherosclerotic unstable plaques
Fan, Xuesong
Gu, Chun
Wang, Xianyun
Wang, Fang
Yang, Jinjing
Cai, Lin
Cong, Xiangfeng
Chen, Xi
CARDIOLOGY, 2013, 126 : 55 - 55
[37] Coronarographic and pathomorphological characteristics of unstable atherosclerotic plaques in acute coronary syndromes
V. D. Rozenberg
L. M. Nepomnyashchikh
Bulletin of Experimental Biology and Medicine, 2007, 144 : 261 - 266
[38] Stable and unstable atherosclerotic plaques: Plaque biology in relation to acute events
van der Wal, AC
Becker, AE
ADVANCED IMAGING IN CORONARY ARTERY DISEASE: PET, SPECT, VRI, IVUS, EBCT, 1998, 202 : 1 - 14
[39] THE BLOOD BIOMARKERS ASSOCIATED WITH UNSTABLE ATHEROSCLEROTIC PLAQUES IN PATIENTS WITH CORONARY ATHEROSCLEROSIS
Kashtanova, E.
Polonskaya, Y.
Stakhneva, E.
Kurguzov, A.
Murashov, I.
Shramko, V.
Ragino, Y.
ATHEROSCLEROSIS, 2019, 287 : E278 - E278
[40] Transcriptomic and Proteomic Profiling of Human Stable and Unstable Carotid Atherosclerotic Plaques
Bao, Mei-hua
Zhang, Ruo-qi
Huang, Xiao-shan
Zhou, Ji
Guo, Zhen
Xu, Bao-feng
Liu, Rui
FRONTIERS IN GENETICS, 2021, 12

← 1 2 3 4 5 →