Immunoregulatory effects of HO-1: how does it work?

被引：83

作者：

Soares, Miguel P. ^{[1
]}

Marguti, Ivo ^{[1
]}

Cunha, Andreia ^{[1
]}

Larsen, Rasmus ^{[1
]}

机构：

[1] Inst Gulbenkian Ciencias, P-2780156 Oeiras, Portugal

来源：

CURRENT OPINION IN PHARMACOLOGY | 2009年 / 9卷 / 04期

关键词：

HEME OXYGENASE-1-DEFICIENT MICE; ARYL-HYDROCARBON RECEPTOR; DENDRITIC CELL MATURATION; CARBON-MONOXIDE SUPPRESS; REGULATORY T-CELLS; OXIDATIVE STRESS; IMMUNE-SYSTEM; DYING CELLS; OXYGENASE; EXPRESSION;

D O I：

10.1016/j.coph.2009.05.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The heme-catabolizing enzyme heme oxygenase-1 (HO-1; encoded by the Hmox1 gene) inhibits the pathogenesis of several immune-mediated inflammatory diseases. This unusually broad salutary effect is thought to rely on the immunoregulatory actions of HO-1, exerted on innate and adaptive immune cells. According to this notion, HO-1 'dampens' innate and adaptive immune responses, limiting immune-mediated tissue injury and thus suppressing the pathogenesis of immune-mediated inflammatory diseases. We will argue that the salutary effects of HO-1 are also exerted via its cytoprotective action, which sustains tissue function and prevents unfettered immune activation by endogenous proinflammatory ligands released from injured cells.

引用

页码：482 / 489

页数：8

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