Immunoregulatory effects of HO-1: how does it work?

被引：83
|
作者：
Soares, Miguel P. [1 ]
Marguti, Ivo [1 ]
Cunha, Andreia [1 ]
Larsen, Rasmus [1 ]
机构：
[1] Inst Gulbenkian Ciencias, P-2780156 Oeiras, Portugal
来源：
CURRENT OPINION IN PHARMACOLOGY | 2009年 / 9卷 / 04期
关键词：
HEME OXYGENASE-1-DEFICIENT MICE; ARYL-HYDROCARBON RECEPTOR; DENDRITIC CELL MATURATION; CARBON-MONOXIDE SUPPRESS; REGULATORY T-CELLS; OXIDATIVE STRESS; IMMUNE-SYSTEM; DYING CELLS; OXYGENASE; EXPRESSION;
D O I：
10.1016/j.coph.2009.05.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The heme-catabolizing enzyme heme oxygenase-1 (HO-1; encoded by the Hmox1 gene) inhibits the pathogenesis of several immune-mediated inflammatory diseases. This unusually broad salutary effect is thought to rely on the immunoregulatory actions of HO-1, exerted on innate and adaptive immune cells. According to this notion, HO-1 'dampens' innate and adaptive immune responses, limiting immune-mediated tissue injury and thus suppressing the pathogenesis of immune-mediated inflammatory diseases. We will argue that the salutary effects of HO-1 are also exerted via its cytoprotective action, which sustains tissue function and prevents unfettered immune activation by endogenous proinflammatory ligands released from injured cells.
引用
收藏
页码：482 / 489
页数：8
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