Clindamycin modulates inflammatory-cytokine induction in lipopolysaccharide-stimulated mouse peritoneal macrophages

被引：23

作者：

Nakano, T ^{[1
]}

Hiramatsu, K ^{[1
]}

Kishi, K ^{[1
]}

Hirata, N ^{[1
]}

Kadota, J ^{[1
]}

Nasu, M ^{[1
]}

机构：

[1] Oita Med Univ, Dept Internal Med 2, Hasamo, Oita 8795593, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 01期

关键词：

D O I：

10.1128/AAC.47.1.363-367.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We investigated the mechanism by which clindamycin (CLI) modulates cytokine induction after lipopolysaccharide (LPS) stimulation. Although CLI decreased the intracellular expression levels of tumor necrosis factor alpha and interleukin 1beta (IL-1beta) and increased IL-6 expression in macrophages, cytokine mRNA expression levels were similar in CLI-treated and untreated groups. Our findings suggest that CLI modulates cytokine production in LPS-stimulated macrophages.

引用

页码：363 / 367

页数：5

共 50 条

[31] Anti-Inflammatory Effects of the Methanol Extract of Sedum telephium ssp maximum in Lipopolysaccharide-Stimulated Rat Peritoneal Macrophages
Altavilla, Domenica
Polito, Francesca
Bitto, Alessandra
Minutoli, Letteria
Miraldi, Elisabetta
Fiumara, Tiziana
Biagi, Marco
Marini, Herbert
Giachetti, Daniela
Vaccaro, Mario
Squadrito, Francesco
PHARMACOLOGY, 2008, 82 (04) : 250 - 256
[32] Tristetraprolin Mediates Anti-inflammatory Effects of Nicotine in Lipopolysaccharide-stimulated Macrophages
Joe, Yeonsoo
Kim, Hyo Jeong
Kim, Sena
Chung, Jiwha
Ko, Myoung Seok
Lee, Won Hyeok
Chang, Ki Churl
Park, Jeong Woo
Chung, Hun Taeg
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (28) : 24735 - 24742
[33] Cholecystokinin Inhibits Inducible Nitric Oxide Synthase Expression by Lipopolysaccharide-Stimulated Peritoneal Macrophages
Saia, Rafael Simone
Mestriner, Fabiola Leslie
Bertozi, Giuliana
Cunha, Fernando Queiroz
Carnio, Evelin Capellari
MEDIATORS OF INFLAMMATION, 2014, 2014
[34] Entomopathogenic Fungus Cordyceps tenuipes Inhibited Inflammatory Mediators in Lipopolysaccharide-stimulated Macrophages
Xiong, Jia
Wickramasinghe, Purni
Munafo, John P., Jr.
Esposito, Debora
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 2020, 56 (01) : S32 - S32
[35] Effect of dual targeting procyanidins nanoparticles on metabolomics of lipopolysaccharide-stimulated inflammatory macrophages
Tie, Shanshan
Zhang, Lijuan
Li, Bin
Xing, Shanghua
Wang, Haitao
Chen, Yannan
Cui, Weina
Gu, Shaobin
Tan, Mingqian
FOOD SCIENCE AND HUMAN WELLNESS, 2023, 12 (06) : 2252 - 2262
[36] Anti-inflammatory Effects of (-)-Epicatechin in Lipopolysaccharide-Stimulated Raw 264.7 Macrophages
Wang, Hai
Cao, Zhi-Ran
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2014, 13 (09) : 1415 - 1419
[37] Bromosulfophthalein suppresses inflammatory effects in lipopolysaccharide-stimulated RAW264.7 macrophages
Cui, Fuai
Sequeira, Sean B.
Huang, Zhenyue
Shang, Guowei
Cui, Quanjun
Yang, Xinlin
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2020, 42 (05) : 456 - 463
[38] Cytoprotective and anti-inflammatory effects of kernel extract from Adenanthera pavonina on lipopolysaccharide-stimulated rat peritoneal macrophages
Arunagirinathan Koodalingam
Ramar Manikandan
Munisamy Indhumathi
Ethala Subramani Kaviya
Asian Pacific Journal of Tropical Medicine, 2015, (02) : 112 - 119
[39] Elasticity and adhesion of resting and lipopolysaccharide-stimulated macrophages
Leporatti, S
Gerth, A
Köhler, G
Kohlstrunk, B
Hauschildt, S
Donath, E
FEBS LETTERS, 2006, 580 (02): : 450 - 454
[40] Effect of dual targeting procyanidins nanoparticles on metabolomics of lipopolysaccharide-stimulated inflammatory macrophages
Shanshan Tie
Lijuan Zhang
Bin Li
Shanghua Xing
Haitao Wang
Yannan Chen
Weina Cui
Shaobin Gu
Mingqian Tan
FoodScienceandHumanWellness, 2023, 12 (06) : 2252 - 2262

← 1 2 3 4 5 →