Clindamycin modulates inflammatory-cytokine induction in lipopolysaccharide-stimulated mouse peritoneal macrophages

被引：23
|
作者：
Nakano, T [1 ]
Hiramatsu, K [1 ]
Kishi, K [1 ]
Hirata, N [1 ]
Kadota, J [1 ]
Nasu, M [1 ]
机构：
[1] Oita Med Univ, Dept Internal Med 2, Hasamo, Oita 8795593, Japan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 01期
关键词：
D O I：
10.1128/AAC.47.1.363-367.2003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We investigated the mechanism by which clindamycin (CLI) modulates cytokine induction after lipopolysaccharide (LPS) stimulation. Although CLI decreased the intracellular expression levels of tumor necrosis factor alpha and interleukin 1beta (IL-1beta) and increased IL-6 expression in macrophages, cytokine mRNA expression levels were similar in CLI-treated and untreated groups. Our findings suggest that CLI modulates cytokine production in LPS-stimulated macrophages.
引用
收藏
页码：363 / 367
页数：5
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