Clindamycin modulates inflammatory-cytokine induction in lipopolysaccharide-stimulated mouse peritoneal macrophages

被引：23
|
作者：
Nakano, T [1 ]
Hiramatsu, K [1 ]
Kishi, K [1 ]
Hirata, N [1 ]
Kadota, J [1 ]
Nasu, M [1 ]
机构：
[1] Oita Med Univ, Dept Internal Med 2, Hasamo, Oita 8795593, Japan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 01期
关键词：
D O I：
10.1128/AAC.47.1.363-367.2003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We investigated the mechanism by which clindamycin (CLI) modulates cytokine induction after lipopolysaccharide (LPS) stimulation. Although CLI decreased the intracellular expression levels of tumor necrosis factor alpha and interleukin 1beta (IL-1beta) and increased IL-6 expression in macrophages, cytokine mRNA expression levels were similar in CLI-treated and untreated groups. Our findings suggest that CLI modulates cytokine production in LPS-stimulated macrophages.
引用
收藏
页码：363 / 367
页数：5
相关论文
共 50 条
  • [1] Effect of Kramecyne on the Inflammatory Response in Lipopolysaccharide-Stimulated Peritoneal Macrophages
    Sanchez-Miranda, E.
    Lemus-Bautista, J.
    Perez, S.
    Perez-Ramos, J.
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2013, 2013
  • [2] Bidirectional effects of moxifloxacin on the pro-inflammatory response in lipopolysaccharide-stimulated mouse peritoneal macrophages
    Qiu, Zhenyu
    Yuan, Hongxia
    Li, Na
    Yang, Xinjuan
    Hu, Xuemei
    Su, Fengtai
    Chen, Baiyi
    MOLECULAR MEDICINE REPORTS, 2018, 18 (06) : 5399 - 5408
  • [3] Anti-inflammatory effects of Chrysophyllum cainito fruit extract in lipopolysaccharide-stimulated mouse peritoneal macrophages
    Arana-Argaez, Victor Ermilo
    Mena-Rejon, Gonzalo J.
    Torres-Romero, Julio Cesar
    Lara-Riegos, Julio Cesar
    Lopez-Miron, Gumersindo
    Carballo, Ruben M.
    INFLAMMOPHARMACOLOGY, 2021, 29 (02) : 513 - 524
  • [4] Anti-inflammatory effects of Chrysophyllum cainito fruit extract in lipopolysaccharide-stimulated mouse peritoneal macrophages
    Víctor Ermilo Arana-Argáez
    Gonzalo J. Mena-Rejón
    Julio Cesar Torres-Romero
    Julio Cesar Lara-Riegos
    Gumersindo López-Mirón
    Rubén M. Carballo
    Inflammopharmacology, 2021, 29 : 513 - 524
  • [5] IL-4 pretreatment selectively enhances cytokine and chemokine production in lipopolysaccharide-stimulated mouse peritoneal macrophages
    Major, J
    Fletcher, JE
    Hamilton, TA
    JOURNAL OF IMMUNOLOGY, 2002, 168 (05): : 2456 - 2463
  • [6] Characterization of lipopolysaccharide-stimulated cytokine expression in macrophages and monocytes
    Haiqiu Huang
    Arnetta Fletcher
    Yuge Niu
    Thomas T. Y. Wang
    Liangli Yu
    Inflammation Research, 2012, 61 : 1329 - 1338
  • [7] Vanillic acid inhibits inflammatory mediators by suppressing NF-κB in lipopolysaccharide-stimulated mouse peritoneal macrophages
    Kim, Min-Cheol
    Kim, Su-Jin
    Kim, Dae-Seung
    Jeon, Yong-Deok
    Park, Sung Joo
    Lee, Ho Sub
    Um, Jae-Young
    Hong, Seung-Heon
    IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2011, 33 (03) : 525 - 532
  • [8] Characterization of lipopolysaccharide-stimulated cytokine expression in macrophages and monocytes
    Huang, Haiqiu
    Fletcher, Arnetta
    Niu, Yuge
    Wang, Thomas T. Y.
    Yu, Liangli
    INFLAMMATION RESEARCH, 2012, 61 (12) : 1329 - 1338
  • [9] Bovine dialyzable leukocyte extract modulates the nitric oxide and proinflammatory cytokine production in lipopolysaccharide-stimulated murine peritoneal macrophages in vitro
    Franco-Molina, MA
    Mendoza-Gamboa, E
    Castillo-León, L
    Tamez-Guerra, RS
    Rodríguez-Padilla, C
    JOURNAL OF MEDICINAL FOOD, 2005, 8 (01) : 20 - 26
  • [10] Metallothionein modulates lipopolysaccharide-stimulated tumour necrosis factor expression in mouse peritioneal macrophages
    Kanekiyo, M
    Itoh, N
    Kawasaki, A
    Matsuyama, A
    Matsuda, K
    Nakanishi, T
    Tanaka, K
    BIOCHEMICAL JOURNAL, 2002, 361 (02) : 363 - 369
12345