A Convenient Regioselective Synthesis of Novel 1,4-Phenylenemethylene-6,6′-bis-([1,2,4-triazolo]-[4,3-b][1,2,4]-triazin-7(1H)-ones)

被引：2
|
作者：
Hassaneen, Hamdi M. [1 ]
Saleh, Fatma M. [1 ]
Mohammed, Yasmin Sh. [2 ]
Awad, Enas M. [3 ]
机构：
[1] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt
[2] Natl Org Drug Control & Res, Giza, Egypt
[3] Natl Res Ctr, Res Div Pharmaceut & Drug Ind, Dept Nat & Microbial Prod, Giza, Egypt
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 06期
关键词：
ANTIBACTERIAL AGENTS; ACID-DERIVATIVES; 1,2,4-TRIAZINE; HALIDES; HETEROCYCLES; SYSTEMS; ROUTES;
D O I：
10.1002/jhet.2910
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The target compounds 6,6'-(1,4-phenylenedimethylene)-bis(3-thioxo-1,2,4-triazin-5(1H)-one) 4,5 were prepared from reaction of oxazolone 1 with thiosemicarbazide and 4-phenylthiosemicarbazide, in potassium hydroxide solution, respectively. Reaction of 4 with hydrazonoyl halides 6 afforded triazolotriazine derivatives 7. Also, 5 reacted with 6 to give the corresponding substitution products 8. Antimicrobial and antitumor activities for some compounds were studied.
引用
收藏
页码：3015 / 3022
页数：8
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